Pitalgin's tablet contains active ingredients: paracetamol, caffeine, naproxen, pheniramine maleate and Drotaverine Hydrochloride.
Additional components: microcrystalline cellulose, croscarmellose sodium, potato starch, hyprolosis, citric acid, butylhydroxytoluene, titanium dioxide, magnesium stearate, talc, indigo carmine, hypromellose, povidone, polysorbate 80, dyes.
Pharmacodynamics and pharmacokinetics
This combination drug exhibitsanalgesic, anti-inflammatory, antispasmodic and antipyreticEffect. In this case, the therapeutic effect of Pentalgin is determined by the substances contained in it.
For example, as Wikipedia points out, paracetamolis an analgesic antipyreticrendering antipyreticand anestheticthe effect that is achieved by blocking the COX in the nervous system and the effect on pain centers and thermoregulation.
Caffeinerepresents psychostimulanta substance that promotes the expansion of blood vessels in skeletal muscle, heart, and kidney. In addition, mental and physical performance is improved, eliminated fatigueand drowsiness, the permeability of histohematogenous barriers increases, as well as the bioavailability of non-narcotic analgesics, helping to enhance the therapeutic effect. Marked tonic effect, reflected in the vessels of the brain.
Naproxen- this NSAIDswhich manifests anti-inflammatory, antipyreticand analgesican action that is associated with non-selective suppression of the functions of the COX, which regulate the production of prostaglandins.
For Drotaverineis characteristic myotropicantispasmodicthe effect, which is due to the inhibition of PDE 4, manifests an effect on the smooth muscles of the gastrointestinal tract, vessels, organs of the urogenital system and biliary tract.
Histamine H1-receptor blocker substance - Pheniramine - proves antispasmodic and light sedative effect, reduces the manifestations of exudation, enhances the analgesic effect of paracetamol and naproxen.
Indications for use
Main indications for use:
- various types of pain syndromes, for example, radiculitis, joint, muscle pain, during menstruation, neuralgia, algomenorrhea,
- smooth muscle spasm caused by chronic cholecystitis, gallstone disease, renal colic,postcholecystectomy syndrome,
- post-traumatic and postoperative pain, including with inflammatory phenomena,
- catarrhal diseases with febrile syndrome.
Also, the drug will be used as a medicine for toothache, migraine.
There are various contraindications to the use of Pentalgin:
- erosive and ulcerative disorders of the digestive tract,
- GI bleeding,
- intolerance to its components,
- bronchial asthma, recurrent nasal polyposis and paranasal sinuses, intolerance acetylsalicylic acid and other NSAIDs,
- severe hepatic and renal failure,
- processes that inhibit bone marrow hematopoiesis,
- transferred coronary artery bypass,
- diseases of the cardiovascular system
- heavy arterial hypertension,
- age under 18 years old.
Pentalgin is contraindicated in of pregnancy and lactation. Therefore, if during pregnancy there are pains or other disorders, you need to get the appointment of a suitable treatment from a doctor.
Also noted a number of conditions when the drug is prescribed with extreme caution, for example, in: cerebrovascular diseases, diabetes, diseases of peripheral arteries, benign hyperbilirubinemia, gastrointestinal ulcers, renal and hepatic insufficiency of moderate and mild form, viral hepatitis, damage to the liver with alcohol,epilepsy and tendencies to seizures, old age, deficiency of glucose-6-phosphate dehydrogenase, and so on.
When treated with Pentalgin, undesirable effects may develop, for example, allergic reactions, disorders of the nervous, cardiovascular, digestive, urogenital and hematopoietic systems, as well as the senses.
This may be accompanied by symptoms such as: itching, skin rash, urticaria, angioedema, thrombocytopenia,agranulocytosis, leukopenia, anemia, methemoglobinemia, excitement, anxiety, tremor, headachesleep problems dizziness, heartbeat failure, arrhythmia, increase HELL, pain, erosive and ulcerative disorders of the digestive tract, nausea, vomiting, constipation, abnormalities in the kidneys, hearing loss, and so on.
Pentalgin tablets, instructions for use (method and dosage)
Detailed instructions for use Pentalgina indicates that the pills are administered orally, one piece 1-3 times a day. The maximum daily dosage is not more than 4 tablets.
The duration of treatment is determined depending on the violation. For example, as a febrifuge pills Pentalgin green take up to 3 days, as an anesthetic - up to 5 days. If you need to increase the duration of therapy, you need to consult with your doctor.
In cases of the use of tablets for a long time, overdose may occur in high doses, which is accompanied by symptoms: pallor of the skin, anorexia, abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, anxiety, confusion, tachycardia, arrhythmia, hyperthermia, increased urination, headaches, tremor, seizures, and so on.
More severe forms of overdose are: the development of liver failure with increasing encephalopathy, arrhythmia, pancreatitis, coma, death.
Usually treatment includes: gastric lavage, taking activated carbonintroduction of specific antidotebut – acetylcysteine or other drugs, depending on the symptoms.
Pentalgin application with barbiturates, tricyclic antidepressants, rifampicin increases the risk of hepatotoxic effect. Also, this drug is able to enhance the effect of indirect anticoagulants and reduce the effectiveness of uricosuric drugs.
Long-term use of barbiturates reduces the effectiveness of paracetamol. While microsomal oxidation inhibitors, for example, Cimetidinemay reduce its hepatotoxic effect.
Simultaneous use with Diflunisal able to increase the concentration of paracetamol in plasma by 50%, increasing the development of hepatotoxicity.
Determined that Naproxen reduces diuretic effect Furosemide, enhancing the effect of indirect anticoagulants, increasing toxicity sulfonamides, methotrexateand also reducing the elimination of lithium and increasing its content in the composition blood plasma.
Caffeine intake with barbiturates Primidone, anticonvulsants are often amplified metabolism and increased caffeine clearance. The combination of caffeine with zimetidine, oral contraceptives, disulfiram,Ciprofloxacin, Norfloxacin - reduces the metabolism of caffeine.
With the simultaneous use of caffeinated beverages and other means capable of stimulating the nervous system causes its excessive stimulation. Drotaverine noticeably weakens the anti-parkinsonian effect. Levodopa. The use of pheniramine and tranquilizers, hypnotic drugs, MAO inhibitors, can increase the inhibitory effect on the nervous and other systems.
Other medicines containing paracetamol and NSAIDs are contraindicated in conjunction with Pentalgin. Be wary appoint funds designed to alleviate the cold symptoms, nasal congestion and flu.
If a patient takes this drug for more than 7 days, control of peripheral blood parameters and liver function is necessary.
The ability of paracetamol to distort the results of laboratory studies related to the content of glucose and uric acid in the blood plasma is noted.
When you need to determine the 17-ketosteroids, the drug is canceled for 2 days before the study. It should be remembered that naproxen may increase bleeding time.
The effect of caffeine on the nervous system is dependent on its type and can manifest itself either by stimulation or inhibition of nervous activity.
Release form and drug composition
The drug Pentalgin is available in the form of tablets for oral use, covered with a protective film of green color. On one side of the tablet there is an inscription in Latin letters (the name of the drug). The tablets are packaged in a contour of cell membranes of 2, 6, 10 and 12 pieces in a carton box, the instruction is attached to the preparation with a detailed description.
The composition of one tablet contains the following active ingredients:
- Paracetamol - 325 mg,
- Caffeine - 50 mg,
- Naproxen - 100 mg,
- Drotaverine hydrochloride - 40 mg,
- Pheniramine maleate - 10 mg.
In addition, the composition contains auxiliary chemical components.
Pharmacological properties of the drug
The drug Pentalgin is a combination drug whose therapeutic effect is based on the active ingredients that make up the tablet.
Paracetamol - relieves pain of various origin, eliminates fever, is used as part of complex therapy of viral and infectious diseases.
Naproxen - a drug from the group of nonsteroidal anti-inflammatory drugs, has a pronounced anti-inflammatory, antipyretic, analgesic effect on the body. Under the influence of this component, the synthesis of prostaglandins, the mediators of the development of inflammatory processes and pain in the body, is suppressed in the body.
Caffeine is a psychostimulant that promotes vasodilation of the heart, kidneys, and other internal organs. Under the influence of this component, the patient's working capacity increases, lethargy and drowsiness disappear. Caffeine enhances the therapeutic effect of other medicinal components that make up the tablets and has a tonic effect on the blood vessels of the brain.
Drotaverine hydrochloride - relieves spasm, has a relaxing effect on the smooth fibers of muscle tissue, which is lined with internal organs (bladder, uterus, gallbladder, blood vessels).
Pheniramine - belongs to the group of histamine receptor H1 blockers. This component relieves spasm, swelling, enhances the therapeutic effect of Paracetamol and Drotaverin, and also moderately soothes the nervous system.
Dosage and administration
Pentalgin tablets are intended for oral administration. Adult patients are prescribed 1 tablet 1 to 3 times a day, depending on the evidence and the severity of the pain syndrome. A day for an adult can take no more than 4 tablets, and the interval between doses should be at least 6 hours.
It is recommended to swallow the pill immediately, without crushing, drinking plenty of liquid. To avoid irritation of the drug on the mucous membranes of the gastrointestinal tract, the pill should be taken after meals.
The duration of the course of drug therapy is determined by the doctor depending on the evidence, but it is not recommended to take the tablets for more than 3 days, since in this case the risk of side effects and drug ulcers increases. In some cases, drug treatment can be continued up to 5 days with the permission of a doctor and under its control. In the absence of a therapeutic effect on the background of treatment with Pentalgin tablets, during the first day the patient should consult a specialist for a more accurate diagnosis and selection of another drug.
Use during pregnancy and breastfeeding
The drug is contraindicated for use in pregnant women. The active ingredients contained in the tablet can adversely affect the laying of the internal organs of the fetus and cause developmental abnormalities.
Since the components of the drug Pentalgin can be excreted in breast milk, the use of this drug to nursing mothers is contraindicated. If it is necessary to treat a woman, she should stop breastfeeding the baby and temporarily transfer it to an adapted milk formula.
Against the background of the use of the drug (especially for more than 3 days), the following side effects often develop in patients:
- On the part of the digestive tract organs - lesions of the mucous membrane of the gastrointestinal tract, exacerbation of chronic diseases of the alimentary canal, nausea, stomach pain, sometimes vomiting, stool disorders, liver damage, anorexia,
- On the part of the blood system - a decrease in the level of platelets and leukocytes in the blood, anemia, agranulocytosis,
- On the part of the central nervous system - tremor of the limbs, headaches, dizziness, insomnia, lethargy, decreased concentration,
- On the part of the heart and blood vessels - tachycardia, cardiac arrhythmia, increased blood pressure,
- On the part of the urinary system - the development of interstitial nephritis, renal dysfunction,
- Tinnitus, glaucoma, reduced visual acuity in rare cases,
- Allergic reactions - a rash on the skin, the development of angioedema, urticaria, in rare cases anaphylactic shock.
If such clinical signs appear, the patient should immediately discontinue drug therapy and consult a doctor.
Analogs pills Pentalgin
In pharmacies you can find a lot of drugs that have antispasmodic, analgesic and antipyretic effects, however Pentalgin is the undisputed leader, as one tablet can solve most problems. Analogues of this tool are:
Some of these drugs include narcotic analgesics, so they are strictly prescription, in addition, have a number of serious contraindications, so you should always consult with your doctor before replacing Pentalgin with its analogue.
Headaches (cephalgia) affect millions of people around the world. It can occur occasionally or regularly, be quite easy or almost unbearable. Quite often, it worries healthy people and, as a rule, disappears rather quickly, so it is not necessary to resort to taking drugs for a headache.
Muscle pain, or myalgia, is familiar to almost everyone. One has only to overstrain in the gym or pick up a “cold”, as the body can signal us about the violations that have occurred.
Unfortunately, many after 30 years are worried about radiculitis. This is a term that unites a whole range of disorders that occur when a spinal cord is damaged. Roots are formed from processes of nerve cells and leave the spinal cord in front and behind, then join and form the spinal nerves.
The feeling of pain in the teeth, which in medicine is called odontalgia, is familiar to almost everyone. In most cases, odontalgia is caused by these or other problems with the teeth, however, it can also occur with the pathology of other structures of the face and skull, and therefore requires a mandatory visit to a specialist.
Joint pain (arthralgia) is often complained by both young people and the older generation. Such pain brings significant discomfort: it prevents movement, does not allow to work normally and fully relax.
Many women during menstruation suffer from pain in the lower abdomen and / or lower back. Such a phenomenon in medicine is called dysmenorrhea. Pain can be almost invisible, not delivering significant discomfort, and very strong, unbearable, not passing even in a state of complete rest.
Involuntary muscle contraction or muscle groups. It manifests itself suddenly arising sharp or, conversely, nagging and nagging pain. The spastic muscle clamps the blood vessels and nerves, disrupting the nutrition of the tissues, so it is very important to relieve excessive tension in a timely manner.
Migraine is a special disease that is associated with vascular pathology of the brain. It manifests itself with recurring bouts of pain, usually only in one half of the head. Scientists agree that heredity plays a significant role in the appearance of migraine.
Pharmacological subtleties of the effects of drugs on the body
In medical practice, this drug is most often prescribed to patients to reduce body temperature, relieve pain, and counteract the development of inflammation. The pronounced therapeutic effect of pentalgin is based on the simultaneous use of several components:
The basis of the medication is naproxen. This substance belongs to the class of nonsteroidal anti-inflammatory drugs and, due to the effect on the synthesis of prostaglandins in the body, has a pronounced analgesic effect.A non-narcotic analgesic paracetamol is also responsible for the relief of pain in various diseases. This medicine is well known to patients due to its very low threshold of allergic activity. Paracetamol is recommended by pediatricians to reduce body temperature in children from an early age. The natural histamine receptor blocker pheniramine is used in this complex as a stimulant for the action of the first two components. In addition to this property, the substance has a pronounced sedative and sedative effects. Drotaverinum, which has a pronounced antispasmodic effect, is also a part of the drug offered to women. Thanks to the latter, Pentalgin is successfully used for monthly pains. The fifth component of this drug - caffeine, is considered indispensable in various vascular pathologies. It smoothly expands the blood vessels of the heart and brain, enhances the work of the kidneys, reduces swelling of tissues due to the excretion of fluid in the bloodstream. Caffeine increases the absorbability of naproxen and paracetamol in the body of a woman, which greatly enhances the anesthetic and anti-inflammatory effects of these substances.
Due to its unique formula, pentalgin is widely used in medical practice and is included in the treatment of many diseases.
Main indications for prescribing Pentalgin
Basically, this drug is used in the treatment of various inflammatory diseases. Infections of the upper respiratory tract, SARS, diseases of the stomach and intestines are well treated with Pentalgin.
Usually, the medicine is prescribed if the inflammation of the organs and tissues is accompanied by a rise in body temperature, edema, and severe pain. The list of this pathology is quite wide, but in each case the use of the drug must be coordinated with the doctor.
The most positive effect can be achieved when prescribing this medication for various painful manifestations. The pain of any origin can be stopped by this tool.
Best of all, the drug acts if the peripheral nervous system is involved in the onset of pain. Excellent results were obtained in the treatment of various neuralgia, toothache, migraine and pain in the joints and muscles.
Since algodysmenorrhea is a direct indication for the use of this drug, the answer to the question of whether Pentalgin helps with menstruation will be positive.
Look at the video about algomenorrhea:
How to apply the medicine during menstruation
In most cases, the representatives of the fair sex independently try to reduce the pain during PMS and menstruation with the use of an anesthetic. This is a rather vicious practice, as the drug under consideration has a lot of limitations and side effects.
The time after which Pentalgin acts during menstruation depends on the condition of the woman, her pain threshold and the dosage of the agent used.
In the annotation to the medicine, it is recommended to prescribe it to women with pain during menstruation 1 tablet 2 - 3 times a day, while the daily dose should not exceed 4 tablets. The treatment cycle is usually 3 days, it is not recommended to use the medicine for more than 5 days.
With a normal duration of the menstrual cycle, this time should be enough for a woman to relieve pain. Longer treatment is possible only under the supervision of a physician.
In case of drug overdose, patients experience nausea, vomiting, dizziness. Frequent attacks of tachycardia, accompanied by a fall in blood pressure and possible loss of consciousness.
First aid is to wash the stomach, use large doses of activated carbon, increase blood pressure with medical and home remedies. Consultation with an overdose medication is mandatory.
What should be considered a woman
The presence of the five components in the composition of an anesthetic medication often leads to the fact that its use requires some caution on the part of the doctor and patient. For example, the caffeine present in it can affect the psycho-emotional state of a woman.
PMS and painful periods and so cause irritability and aggressiveness in patients, so this drug is designed to calm the nervous system of a woman. In this case, it should be remembered that pentalgin helps with menstruation, but at the same time it causes a decrease in concentration and attention, which is very important when managing vehicles and working with thin instruments.
It is mandatory to conduct laboratory tests of blood and liver function after 7 days of taking the medicine. No less important is the control of blood coagulation, as naproxen, which is part of the drug, increases the time of formation of a blood clot.
It is strictly forbidden to take the drug with alcohol. The medical literature describes a large number of cases of pathological symbiosis of Pentalgin and alcohol. Even doctors do not recommend the simultaneous use of this painkiller and any drops on alcohol.
For a long time, Pentalgin was considered one of the best medicines for relieving painful sensations during menstruation, while the pharmacy price of this medicine is quite democratic. The cost of 4 tablets ranges from 120 to 160 rubles.
We recommend to read the article about the drug "Ibuklin" during menstruation. From it you will learn about the pharmacological action of the drug, indications for use and contraindications, instructions for reception, the effectiveness of menstruation.
Modern pharmacological studies have allowed us to develop a whole range of new drugs to reduce pain in PMS. In the work of Pentalgin, specialists discover ever newer negative qualities. However, despite all this, this drug remains one of the most sought after among patients who have problems with monthly
Sometimes there is a need to relieve or relieve pain. Headache or toothache may occur suddenly, and then urgent action will be required. In this case, the patient is assisted by an analgesic drug, and Pentalgin is considered one of the best in this group.
Pentalgin - composition and effect of the drug
Pentalgin is a popular antispasmodic, combined anipid. It has a complex effect:
The composition of one tablet contains the following substances:
The drug is recommended for use in pains of any intensity, nature and origin. Also, indications are a variety of diseases that are accompanied by feverish states.
Can I use for toothache?
It is possible to take Pentalgin with a toothache, since it is a drug of complex effect, relieving pain sensations of various origins. If odontalgia is taken by surprise and there is no possibility to visit the dentist immediately, taking Pentalgin will help relieve the patient's condition and get rid of the pain for a while.
In case of sudden odontalgia, it is usually sufficient to take a single dose of one pill of the drug - if the pain is very strong, it is allowed to take two tablets at once, but no more. Before taking you should carefully read the instructions, in particular - a list of contraindications. In particular, Pentalgin should not be taken together or immediately before / after alcoholic beverages. After taking the vehicle to drive or to carry out any activity in which you want to concentrate attention is not recommended.
It should be remembered that Pentalgin helps with toothache, but acts not as a medicine, eliminating the root cause of pain, but as a means to relieve symptoms. To postpone a visit to a specialist just because the pain has passed, you should not.
Drug release form
It is produced in the form of biconvex tablets, each of which is covered with a film cover with the impressed name of the drug on one side, whereas an opposite narrow strip is visible on the opposite side. On a pale green cut of green / pale green tablets, white inclusions should be clearly visible. In pharmacies, you can buy medicine in cardboard boxes containing from 2 to 24 tablets placed in blisters.
Currently, domestic and foreign (for example, Bulgarian) pharmaceutical companies are producing four varieties of the drug under consideration, while medicines of each type have some differences in their composition, although all of them effectively act on the human body as spasmolyanalgeics:
Instructions for use and dosage
In accordance with the instructions, it is recommended to take the medicine according to the following scheme: 1 tablet - 3 times a day - interval: 4-hour, not dependent on food intake. Pill orally in whole form (chewing or mechanical grinding is not required). Wash down with water (preferably boiled).
Many are interested in how much Pentalgin works, because the pain can be very intense and the patient needs to remove it as soon as possible. For any pain, a person feels relief on average a quarter of an hour after taking the pill. Duration of the drug: 4-5 hours.
The doctor prescribes a course of treatment individually for each patient. As a rule, the therapeutic course is:
as an antipyretic agent - 3 days (one tablet 1-3 times / day), for diseases of the nervous system or musculoskeletal system, accompanied by intense pain - 5 days (the daily dosage is similar), for toothache a single dose of a single medication effectively eliminate acute short-term pain.
If a person takes Pentalgin for seven or more days in a row, it is necessary to systematically monitor the morphological composition of the blood and liver function. It should also be remembered that excessively taking Pentalgin can cause such a side effect as drug dependence.
Who is the drug contraindicated?
Acceptance of the considered drug is prohibited in a number of cases listed below:
during pregnancy (in all trimesters) and during lactation (in the latter case, if you need to take the drug, you must interrupt feeding), people under the age of 18 (in some cases, prescribed by a doctor, can be used in the treatment of adolescents who have reached 12 years of age age), with individual intolerance to non-steroidal drugs with anti-inflammatory effects, or intolerance (hypersensitivity) of the drug and / or its components, to persons who suffer from functional inadequate liver and / or kidney failure in severe stage, hyperkalemia, persons suffering from diseases of the cardiovascular system, including acute myocardial infarction, severe hypertension, paroxysmal tachycardia, frequent ventricular extrasystole, in the case of if a patient has a function of bone marrow hematopoiesis, patients who have undergone coronary artery bypass surgery in the recent past, patients with nasal sinuses / nose polyposis and / or bronchial asthma, persons diagnosed with tirovannye erosive and ulcerative lesions of the gastrointestinal tract in the acute stage.
Elderly patients, as well as people suffering from gastrointestinal diseases, moderately severe kidney / liver pathologies, epilepsy, or convulsive seizures, people diagnosed with diabetes or hyperbilirubinemia should take the drug with extreme caution. It is recommended to consult a doctor beforehand.
Due to the high efficiency and speed of impact on the body, as well as affordable cost, Pentalgin enjoys unchanged popularity among domestic consumers. Today, pharmaceutical companies produce a number of analogues of this drug, which have a similar composition and pharmacological action: