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Treatment of endometriosis, adenomyosis and hyperplasia with Vizann

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Hormonal tablets reduce the concentration of estrogen in the ovaries and plasma, significantly inhibit the foci of endometriosis, and with prolonged use of the drug, pathology will atrophy.

Exposure to additional properties of the drug prevents cell proliferation. The drug does not belong to the group of contraceptive hormones, although ovulation is suppressed when taken.

Byzanzan for endometrial pathology is prescribed for at least six months, and the medication can be used from any day of the cycle. The activity of the drug does not depend on the time of reception of funds - before meals or after.

Recently, local doctors have been actively using the Vizann drug for endometriosis, who note the high efficacy of the drug in relation to endometriosis of the uterus.

Vizanna helps patients with varying degrees of pathology, because it acts directly on the mechanism of the onset of pathology.

Visanna with adenomyosis

If women are diagnosed with adenomyosis, then the practice of treating this disease also includes the Vizann medicine. This drug strengthens the mucous membrane of the uterine layer and has a progestogenic effect on the functioning of the female reproductive system.

The possibility of use is due to the presence of highly effective active ingredient dienogest. It inhibits the growth of endometrial cells, as it affects the production of female sex hormones.

It is necessary to take Byzanna for adenomyosis in the dosage recommended by a specialist. As a result of drug treatment in women, the growth of abnormal cells stops and a disease such as adenomyosis is eliminated.

Indications and Contraindications

The recommendation for the use of the drug is endometriosis. Therapy with the hormone drug Vizanna helps to normalize the endometrium and reduces its pathological growth.

The following pathologies are contraindicated for use:

  • thromboembolism
  • pathologies of the heart and blood vessels
  • diabetes, which gave complications to the vessels,
  • liver pathologies, organ neoplasms,
  • suspicion or detection of malignant neoplasms,
  • uterine hemorrhages of unknown etiology,
  • excessive sensitivity to the components of the drug.

Dosage and administration

Instructions for use involves oral medication for endometriosis, and you can start from any day of the cycle. Per day you need to take one pill of the drug, it is advisable to drink the drug at one time.

Wash down tablets with a small amount of water. Drink the drug should be without interruption, not paying attention to the bleeding. After completing the packaging, take the pill without interruption.

In the treatment of endometriosis, Visanna should take into account that the therapeutic effect may be reduced. This happens with diarrhea or vomiting that occurs in the first three hours. Then the patient drinks one extra pill to maintain concentration.

For any reason, the tablet was not drunk, you do not need to increase the dose the next day. To cure endometriosis of Visanna, it is enough to take the usual amount, further monitoring the regularity of use.

Treatment regimen

Visanna in the treatment of endometriosis is taken according to a specific scheme. The term of treatment is six months, and the medicine does not depend on the time of the cycle - you can start the application on any day.

It is very important that the tablets are taken daily - this will allow you to constantly maintain the desired concentration of the hormone in the body. Drink for the treatment of endometriosis bezanna need without interruption until the course of therapy is completed.

Reviews gynecologists

Despite the fact that the drug in Russia is used relatively recently, reviews about Vizanna have already been formed by doctors. In specialized forums, they actively exchange the experience of prescribing medications to their patients.

The feedback from the specialists is positive in most cases - doctors note the high effectiveness of the drug in relation to the pathology. 95% of patients who were prescribed a drug for endometriosis, successfully cured of the pathology or significantly reduced the pathological growth of the endometrium to degree 2.

High efficacy against the background of ovarian cyst is also noted - usually patients are operated on, and the medicine is an excellent means to restore the health of the female reproductive system.

When taking the medication, doctors noted an increase in the weight of patients - this is stated in the information sheet. An increase in body weight of 6 kg is possible, but after discontinuing the medication, the silhouette again becomes subtle.

This is both a plus and a minus of Vizanna - reviews by doctors show that even weight gain is beneficial for many patients. Their skin is smoothed, a healthy complexion appears, women become less irritable.

When diagnosed with endometriosis, doctors' reviews are extremely positive, as are the opinions of the patients.

Release form and composition

The drug is available in tablet form. Each tablet is painted white and has a width of 7 mm. The upper part with beveled edges, and on one side there is a groove in the shape of the letter B.

The composition of the drug is mainly dienogest, it contains 2 mg per tablet. Additionally, lactose monohydrate, potato starch, monocrystalline cellulose, magnesium stearate and other components are present.

Use during pregnancy and lactation

Studies of the effect of dienogest during pregnancy did not reveal a teratogenic effect on the fetus, but the drug is not prescribed to pregnant patients, since there is no need for endometriosis therapy in this cohort of patients.

It is not recommended to use the drug during the breastfeeding period, since traces of dienogest were found in breast milk. At the time of treatment lactation should stop.

Dienogest violates the cycle, but its recovery is possible within a couple of months after the cancellation. Despite these features, it can not be used as a contraceptive - it is possible pregnancy, while taking the drug.

In order to get pregnant after the treatment with Visanna, it is necessary to wait 2-3 months after stopping the administration, while the cycle is normalized.

The effect of the drug on the body

The active substance does not have a negative effect on the body. Studies have established the following drug relationships with the pathologies of patients:

  • with cardiopathies, the drug does not significantly affect the possible risks of a heart attack or stroke,
  • the cause-and-effect relationship of the use of the drug and the occurrence of breast cancer has not been proven,
  • in women with uterine abnormalities, bleeding increases, which can lead to anemia.

Before prescribing the medication, a comprehensive examination of the patients is carried out in order not to provoke the worsening of chronic pathologies.

Overdose

Overdose of the drug practically does not occur, because the tablet contains a small amount of the active substance, and when you take an extra tablet overdose will not occur.

Studies show that even a large dose of dienogest does not adversely affect the health of patients. There is no antidote.

The drug is produced by the German pharmaceutical company Bayer, so its price on the Russian market is quite high. 28 tablets of the drug cost about 3,500 rubles, and 84 pieces - 8,500. These are the prices of online pharmacies.

The cost may differ significantly in the direction of increasing if you buy the medicine in ordinary pharmacies. How much is the monetary difference, you can find out by comparing prices in several pharmacy items.

Side effects

As with any drug, medication can have side effects. Usually they are noted in the first days of use of the drug. Among the negative effects on patients noted:

  • weight gain (on average up to 6 kg),
  • depression, fatigue, drowsiness,
  • headaches and migraines,
  • sore back, back,
  • nausea and vomiting,
  • chest discomfort, feeling hot,
  • irritability.

In rare cases, there was a loss of body weight, anemia, shortness of breath, pain in the bones and muscles. If side effects from Vizanna are found, the drug is replaced with an analogue.

Positive experience after Vizanna

Patients who took the drug, noted that after the end of the course of treatment, the state of the endometrium returned to normal, long painful menstruation disappeared.

Many patients felt a positive effect in the middle of the medication.

A huge plus of the drug is a low percentage of side effects. Most patients were successfully treated with medication.

According to a similar principle of action of the drug, the pharmaceutical industry produces several analogues. These include Turinal, Exluton, Lakinet, Norkolut, Jazz, Prajisan.

The mechanism of the drug on the body

Visanna belongs to a class of drugs called gestagens. In fact, synthetic substances act as progesterones in a woman’s body.

Typically, female hormones are produced by the body from infancy, and are essential for the normal sexual development and regulation of the menstrual cycle in girls who have reached childbearing age.

Interesting to know! Progesterones are also produced by the adrenal glands of men. However, the amount of the hormone is extremely small.

The drug Byzanne is prescribed for endometriosis precisely because Dienogest can significantly reduce the negative effects of estrogen on the tissues lining the uterus. The pills also provide an analgesic effect without the severe side effects inherent in Buserelin, Lupron.

What is the scheme to take the drug?

Instructions for use Vizanna with endometriosis prescribes to drink one tablet once a day (2 mg of the active substance of the drug). The course of treatment should last at least 6 months, but the doctor can adjust the dosage and duration of therapy, based on the results of tests and the general health of the patient.

Even if it was possible to buy Vizanna without a prescription (and this is quite possible in domestic pharmacies), in no case do not need to take pills according to the general instructions of the instructions. The fact is that many factors can affect the desired dosage, including:

  • Weight of patient
  • Taking other medicines
  • The number and ratio of major hormones.

How many pills to drink each particular patient decides only the doctor. And if a specialist has prescribed more or less than 2 mg of Dienogest per day, this does not indicate a medical error.

Having decided on the dosage and duration of the course of conservative treatment, it is necessary to familiarize yourself with other (no less important) rules for accepting Vizanna. First, you need to take pills at the same time of day.

Despite the fact that taking the drug Byzanna can lead to the disappearance of ovulation, you should not refuse contraception. The only advice is to replace oral contraceptives with barrier contraceptives.

Secondly, there is no need to take any breaks during the entire course of treatment. As soon as one pack of the drug is finished, you need to start a new one right away, so it is important to ensure that there are always the necessary number of pills in stock.

Tip! Instructions on the reception with or without food, the instructions do not. Therefore, you can drink pills "as convenient", with a small amount of liquid.

If the medicine for endometriosis was accidentally missed, then it is necessary to drink 2 mg of Dienogest again as soon as possible and return to the normal schedule of therapy. If it is time to take the next dose, then drink 2 tablets at the same time is strictly prohibited.

What is adenomyosis?

Pathology such as adenomyosis, is one of the varieties of endometriosis.

In adenomyosis, the endometrium grows not only into the uterine cavity, but, in most cases, beyond its limits.

The disease affects women from 20 years to 50 years, while the exact cause of its development has not yet been established.

However, there are a number of factors that can trigger the development of adenomyosis:

  • frequent stress and psycho-emotional stress,
  • excessive exercise
  • genetic predisposition
  • endocrine system diseases
  • failure of the immune system,
  • hormonal disorders.

Read about the symptoms of this disease here.

Drug description

The main component of the Vizanna is dienogest. This substance is considered a chemical derivative of Nortestosterone, which is characterized by high antiandrogenic activity.

Auxiliary substances included in the composition are:

  • talc,
  • potato starch,
  • lactose monohydrate,
  • Povidone K25,
  • microcrystalline cellulose,
  • Crospovidone,
  • magnesium stearate.

Visanna has a progestogenic effect on the woman's body, which, in turn, suppresses the action of the female hormone - estrogen.

When taking Vizanna on the body of a woman is the following effects:

  • the effect of estrogen on the foci of adenomyosis is significantly reduced,
  • adenomyotic foci are reduced when taking Byzanna,
  • a decrease in the level of the hormone - estrogen and a decrease in its production in the ovaries.

Metabolization of the main substance of the drug Vizanna occurs in the liver, and decomposition products are derived naturally by urination.

Some women who start a course of therapy begin to have irregular menstruation. Worry about this is not worth it, because the cycle is fully restored some time after the drug is stopped.

When correctly applied, Visanna begins, after a while, to affect the genital organ in that it reduces the formation of the endometrium on the inner walls of the muscular tissue of the uterine wall. When taking the drug adenomyosis foci begin to gradually decrease, and then completely disappear.

Advantages and disadvantages

Like any other drug, Vizanna has a number of advantages and disadvantages that must be taken into account before starting to use the drug.

Benefits:

  • The main advantage of this drug is its effectiveness in the treatment of endometriosis and adenomyosis. Visanna not only helps to stop the growth of the endometrium, the resorption of the affected lesions, but also minimizes the risk of recurrent endometriosis or adenomyosis,
  • women who have been trying to get pregnant for a long time have the opportunity to conceive a child,
  • Visanna also has an analgesic effect, in particular, when taking the drug, the pain syndrome decreases during critical days,
  • hormonal background when taking Vizanna stabilizes and works without disturbances,
  • Accepting Vizanna does not hinder such a process as the maturation of an egg, and therefore there is a high probability that a woman, having stopped taking Vizanna, can become pregnant immediately after the first sexual contact.

Disadvantages:

  • One of the main drawbacks of the remedy is that after it is taken it may increase blood clotting. Therefore, for women with varicose veins and having a predisposition to the formation of blood clots, this drug should be used with caution. Women predisposed to the formation of blood clots, should be told about this by the attending physician before starting taking the drug, in this case, the physician, in order to avoid serious consequences, prescribes Aspirin in combination with Visanna, which helps prevent thrombus formation,
  • in some cases, the reception of Vizanna can provoke uterine bleeding. In this case, you can’t try to stop the bleeding on your own, but seek immediate medical attention.
  • it often happens that a woman begins to perspire strongly when taking a Byzantium,
  • Another disadvantage is that a woman can start bleeding profusely. In this case, you should immediately consult a doctor, as this may provoke the development of anemia. The physician should prescribe a replacement drug, or hemostatic agent to the patient.

Indications for use

Such a drug as Vizanna is prescribed for focal, diffuse and nodular adenomyosis of the first, second or third degree. The fourth degree of adenomyosis is rarely amenable to drug therapy.

The main indications for taking the drug are:

  • endometriosis and adenomyosis,
  • heavy bleeding that does not stop for a long time during menstruation,
  • pregnancy planning,
  • reduction or relief of pain during menstruation.

Dienogest, which is part of the product, can be used as an independent substance, and in complex therapy.

How to use

Sale of the drug in the form of tablets of 2 mg, which must be taken once a day. It is necessary to use tablets at the same time irrespective of meal.

The course of treatment is 6 months, you can start it on any day of the menstrual cycle.

You can not miss taking the drug, as this may decrease its effectiveness.

If for some reason it was not possible to drink the pill at the appointed time, then the next day, a double dose of the drug is recommended, and the next time the agent is taken again according to the old scheme.

Contraindications and possible consequences

Despite the fact that Vizanna is a highly effective drug, there are a number of pathologies in which the use is contraindicated:

  • diseases of the liver, kidneys and cardiovascular system,
  • pregnancy and lactation,
  • allergic to component products
  • diseases of the endocrine system, in particular diabetes mellitus at any stage of development,
  • suspicion of the development of any cancer,
  • neurological pathologies associated with frequent headaches, depression, baseless irritability,
  • atherosclerosis of vessels in an acute form.

Visanne is contraindicated for girls under 18 years old!

Uncontrolled intake of the drug can lead to the development of side effects, so it is very important to use it in accordance with the recommendations of the doctor.

The main consequences that may be caused by the use of Vizanna are:

  • weakness and fatigue
  • nausea, pain in the abdomen,
  • headaches,
  • an increase in the weight of a woman, in some cases, taking the drug can, on the contrary, provoke a decrease in body weight,
  • anemia,
  • Sometimes women taking the drug Vizanna, for unreasonable reasons, may experience depression.

Content

In recent years, the representatives of the weaker sex more often revealed such a gynecological disease, such as adenomyosis, Vizanna has various reviews in the treatment of such a pathology. But to obtain a positive result, it is important to conduct treatment under the supervision of a physician.

Adenomyosis is a gynecological disease, the progression of which is accompanied by the germination of the endometrium in other layers of the reproductive organ. Most often, this pathology becomes the cause of infertility in women, therefore, requires mandatory treatment. The elimination of female disease is carried out using various methods and Vizanna is considered one of the most effective drugs.

Characteristic pathology

Uterine adenomyosis is considered to be a complex gynecological disease, which is diagnosed in women after 30 years. With the progression of such a disease in the body of women is the growth of endometriotic tissue in the muscle layer of the reproductive organ. In addition, the penetration of endometrial particles into adjacent organs is possible, which results in a violation of their functioning.

This pathology of the reproductive organ is characterized by the development of the following features:

  • The formation of dark brown discharge a few days before the onset of menstruation or immediately after them,
  • The development of postmenstrual syndrome,
  • Spotting during menstruation becomes abundant,
  • A woman begins to worry about pain in the pelvis,
  • There are failures in the menstrual cycle,
  • Sexual intercourse causes discomfort and discomfort in the patient,
  • The reproductive organ changes its shape and size.

Most often, the main reason for the occurrence of pregnancy for a long time becomes adenomyosis. Penetration into the muscle layer of the reproductive organ of pathological cells leads to the fact that they begin to actively grow. However, a characteristic feature of this pathology is the fact that such cells do not go out during menstruation, which provokes hemorrhages and the development of the inflammatory process.

To date, the causes that cause the development of such a pathology in the genital organ are not fully understood.

Experts identify some adverse factors, the impact of which on the female body can trigger the development of the disease:

  • Constant stressful situations and overstrain of the body,
  • Active image, which is accompanied by increased physical activity at work,
  • The genetic factor, that is, the pathology of the uterus can be inherited,
  • A passion for tanning and sunbathing
  • Various surgical interventions, especially abortions and scraping.

This pathology requires compulsory treatment, which can be carried out using:

  • Therapeutic methods
  • Surgical intervention.

The elimination of the disease is carried out with the use of medications, the reception of which allows you to restore the hormonal background of the female body and normalize the immune system. Thanks to this therapy, it is possible to stabilize the work of the female body for several months and in each specific situation the necessary terms of treatment are determined.

When choosing a particular method of treatment pay attention to the following factors:

  • Woman's age
  • Degree of disease progression,
  • Planning to have a baby.

If adenomyosis provokes the emergence of acute pain, the treatment of pathologists of the uterus is carried out with the help of nonsteroidal agents that have anti-inflammatory effects. Such therapy usually lasts for several days and is prescribed a few days before the start of the month.

After completing the course, it is possible to normalize the hormonal background of the female body and restore the menstrual cycle.

In that case, if conservative treatment does not give the desired effect, then adenomyosis is eliminated with the help of surgery. The purpose of the operation is the elimination of pathological foci and the restoration of the normal structure of the genital organ.

For adenomyosis, the following types of surgery are performed:

  1. Electrocoagulation involves the removal of pathological foci under the influence of electric current.
  2. Embolization is the overlap of vessels through which blood moves to a neoplasm.
  3. Ablation is aimed at the destruction of the inner shell of the reproductive organ.

Completely get rid of the symptoms of endometriosis is possible only during the operation to remove the genital organ.

Purpose of the Vizanna in case of illness

When identifying such a gynecological disease as adenomyosis, experts must prescribe treatment. One of the most effective drugs that helps get rid of this pathology is considered Byzanna. Such a hormonal agent has a strengthening effect on the mucous membrane of the reproductive organ and has a gestagenic effect.

The main component ingredient of this drug is dienogest, which makes the drug highly effective. Its main action is aimed at reducing the intensive growth of endometrial cells in the uterus due to the inhibitory effect on female sex hormones. In the event that Byzanna is taken in accordance with the recommendations of a specialist and in compliance with the required dosage, it is possible to suppress the growth of foci of the inflammatory process in the uterine cavity.

It is important to remember that Byzanna is a drug, so treatment with it should be carried out under the supervision of a specialist. Independent use of such a tool can only worsen the condition of a woman and cause the development of many complications. When carrying out treatment with the help of a hormonal agent, it is necessary to strictly follow all the prescriptions of the doctor and not use it to treat other pathologies.

Treatment with the help of Byzanna has some features:

  • The course of drug therapy with this drug is 6 months,
  • You can start treatment on any day of the menstrual cycle,
  • You can take medicine at any time of the day, both before and after meals.

It is important to observe the dosage specified by the specialist, which increases the chances of a quick recovery.

Contraindications and side effects

Despite the high effectiveness of such a hormonal drug in the treatment of adenomyosis, sometimes its use will have to be abandoned.

The drug is not prescribed in the following conditions:

  • Identification of a female cardiovascular disease,
  • The progression of atherosclerosis,
  • During pregnancy and breastfeeding,
  • Impaired kidney and liver function
  • Tendency to develop allergic reactions.

When conducting an uncontrolled therapy at home, the risk of developing side effects increases when taking Bezanne. In some cases, they can appear even with normal drug intake, however, they quickly disappear.

In the fight against adenomyosis, hormonal medication may cause the following side effects:

  • Frequent headaches
  • General weakness of the whole body,
  • Pain in the abdomen,
  • Bouts of nausea
  • Slight increase in patient weight.

In rare cases, the following side effects may occur:

  • Anemia,
  • Permanent depression
  • Weight loss.

When taking Vizanna in the treatment of gynecological diseases requires the mandatory waiver of the use of alcohol, which reduces its effectiveness. It is important to remember that the removal of adenomyosis is necessary under the supervision of an experienced specialist, which will prevent the development of various complications and side effects in women.

Opinions of patients about the drug

You can find various reviews about such a hormonal drug like Byzanna. This drug is used to combat adenomyosis not so long ago, but the reviews about it are in most cases positive.

Ekaterina, 35 years old, Ivanovo

A few years ago, I was diagnosed with adenomyosis, which caused me a lot of anxiety. The gynecologist recommended to undergo a course of drug therapy with the help of such a drug as Vizanna. I wanted to read the girls' reviews about this medicine, but I didn’t find anything, because the drug is new. Still, I decided to take a chance and underwent a course of treatment with the help of a hormonal agent for 6 months. I managed to completely get rid of all pathological processes in the uterus, but still periodically visit the doctor to monitor the condition.

Natalia, 28 years old, Irkutsk

My feedback on Byzanna is only positive, because it was only thanks to this medicine that I managed to get rid of such an unpleasant disease as adenomyosis. This pathology caused me constant pain in the lower abdomen, and I suffered from infertility for a long time. Vizanna helped me get rid of severe pain, and after undergoing a course of treatment after three months I was able to get pregnant on my own.

Tatiana, 21, Moscow

Now I am undergoing treatment for adenomyosis with the help of Vizanna. At first I was a bit worried because I had read various reviews about such a drug, but I nevertheless decided. I have been taking the remedy for three months, and during this time I managed to get rid of lower abdominal pain. The only drawback for taking this drug for me was the nausea that bothered me in the first month of treatment.

Svetlana, 25 years old, Minsk

The specialist revealed adenomyosis in me and recommended treatment with Byzanna. I have been taking the drug for almost five months now, and have noticed a significant improvement in my condition. An ultrasound scan showed that the foci of inflammation in the uterus almost disappeared, so I am pleased with the result.

Valentina, 31, Moscow

I can confidently call my treatment with the help of Vizanna effective, since I have almost completely disappeared adenomyosis. Among the small flaws, I would like to highlight the fact that my taking this drug caused a small weight gain. Now, getting rid of gynecological disease, we have to think about how to get rid of excess weight.

Vizanna is considered a highly effective drug that is widely used to eliminate adenomyosis. It is important to remember that the treatment of any gynecological disease should be carried out under the supervision of a specialist, and it is best to refuse self-treatment.

Main component

Among the active ingredients of the drug, only one substance is dienogest, which is characterized by increased antiandrogenic activity. It has a relative relationship with progesterone, due to which it has a strong progestogenic effect.

The main active ingredient binds to receptors in the reproductive organ and thus has a therapeutic effect. In the treatment of endometriosis Byzanna, the production of estradiol is reduced, and its trophic effect is suppressed. With prolonged exposure to the body, the active component creates a special endocrine environment and provokes flaking of the lesions. At the final stage of therapy, the endometroid sites will completely atrophy.

The effect is enhanced by the presence in the medication of such excipients as magnesium, starch, lactose, talc and crospovidone.

Action on the body

The drug Vizanna with endometriosis has the following effect:

  • prevents the onset of the inflammatory process,
  • reduces the intensity of pain during the critical days,
  • prevents further growth of the endometrium,
  • eliminates uterine bleeding,
  • normalizes hormones,
  • has a sustained analgesic effect.

Unlike other drugs, this medicine does not interfere with the process of maturation of the egg. It is noted that after cessation of therapy, a woman can become pregnant at the first sexual intercourse.

How is the treatment carried out?

Tell a doctor about how to take Bezanne for endometriosis. Hormone therapy is carried out according to a specific scheme with strict adherence to dosage. Reception does not stop even during menstruation.

Treatment control

All progestogens are able to provoke increased luteal and follicular activity. For this reason, the appearance of cystic formations in the area of ​​the appendages, which are associated with the use of Vizanna, is not excluded.

Monitoring the effectiveness of the course and the analysis of the woman’s condition is first carried out after three months of taking the drug. At the end of therapy, ultrasound and gynecological examination are recommended every six months.

In order to assess performance, the following surveys are conducted:

  • Ultrasound examination of the abdominal cavity and pelvic organs,
  • urine and blood tests
  • blood chemistry,
  • coagulogram,
  • blood pressure measurement
  • general practitioner consultation
  • assessment of the state of the uterus and mammary glands.

Analogs of the drug

Similar with Visanna on the principle of action of drugs are the following:

Most often, Vizanna in the treatment of endometriosis is replaced by the drug Janine, also able to cope with this disease.

One of the most effective drugs in the treatment of endometriosis is considered to be Silhouette, therefore we recommend reading the detailed instructions for its use.

Which is better: Byzanna or Janine

Both drugs are considered among the best medicines used in the fight against endometriosis. It is quite difficult to answer unequivocally what is more effective, Janine or Byzanna. These drugs belong to the group of hormonal agents that can suppress the pathological proliferation of the endometrium. The choice should be carried out exclusively by the doctor. In each case, the gynecologist will prescribe a certain drug, taking into account the clinical picture, the general state of health and the extent of the lesion.

Sometimes the doctor prescribes treatment without hormones, so you should additionally read information about existing non-hormonal drugs and drugs.

Visanna is a hormonal agent that can stop the growth of the endometrium. It is often used in the treatment of endometriosis. The drug is very reliable in the fight against pathology, but can cause side effects. It should be taken only as prescribed by a doctor and only after a thorough diagnosis. Only in this case, therapy will be safe and effective.

What is Byzanna

Vizanna (dienogest 2 mg) is a synthetic progestogen, the original drug of the German pharmaceutical giant Bayer Weimar GmbH and Co.

Generics (analogs) Byzanna: today does not exist

Drug byzanna

  • In 1 blister 14 tablets.
  • In one carton box:
    2 blisters: 28 tablets (2x14) or
    6 blisters: 84 tablets (6x14) or
    12 blisters: 168 tablets (12x14).
  • The tablets are white (almost white), the surface is flat, the edges are beveled.
  • On one of the surfaces of the tablet logo "B".

Blister of the drug Byzanne

Price: for one package of Vizanna (2x14)
from 2600 rubles and above

Dienogest is an active substance and the international non-proprietary name of Vizanna. It is a special hybrid steroid with a pronounced progestogenic activity 1 which significantly exceeds the effects of natural progesterone on the endometrium.

1 Progestogenic activity - action similar to that of progesterone on target organs, including the endometrium.

How do female sex hormones act on the endometrium? What is different from other progestin?

Dienogest - a representative of hybrid drugs. It differs significantly from the known types of progestogens: chemical formula, small size of the molecule, other new characteristics.

Thanks to hybridization, dienogest combined the positive properties of progesterone and 19-nortestosterone.

Byzanna possesses high receptor specificity 1 progesterone.

1 Биологическая активность стероидов определяется наличием в клетках любых тканей различных specific receptor proteins to certain hormones.

Getting into the blood highly specific Bioactive substances (natural or synthetic) can bind with only one type of receptor. Less specific "collaborate" with several. This explains the number of unwanted side effects of many hormonal drugs.

Dienogest does not show affinity for estrogen receptors, androgens, and corticosteroids or, according to most researchers, it is extremely insignificant. Therefore, Byzanna practically does not produce the extra effects inherent in many gestagens.

Specificity of Vizanna to progesterone receptors

Benefits of Byzanna

  1. Unique bioavailability (90-91%) when taken orally (thanks to micronization and new "hybrid" characteristics).
  2. Strong selective effect on the endometrium.
  3. High efficiency with a low therapeutic dose (in comparison with other progestogens): only 2 mg of dienogest per day is enough for complete transformation of the proliferative endometrium into the secretory one.
  4. Linear pharmacokinetics: Byzanna is rapidly excreted from the body, does not accumulate in organs and tissues.
  5. Dienogest enters the body already in the active form, i.e. begins to act immediately after admission to the blood.
  6. Visanna is not an anti-estrogen, therefore it does not significantly affect the state of the cardiovascular system, it is not accompanied by tides, other symptoms of menopause.
  7. Visanna does not exhibit androgenic and corticoid activity, so even with long-term use it does not cause signs of muscularization (male pattern hair loss or hair growth, acne, etc.), weight gain, significant increase in blood pressure, development of osteoporosis, deterioration of the lipid and carbohydrate profile , changes in the composition of the blood.

Additional effects of some progestogens Byzanna is safe and well tolerated even with prolonged,
up to 15 months, welcome.
Clinically significant effects of Vizanna

  • Progestogenic
  • Antiandrogenic
Indications for use Vizanna
  • External genital endometriosis.
  • Internal endometriosis or adenomyosis.
  • Extragenital endometriosis.
Visanna is highly effective in the mild and moderate stages of endometriosis. Expected therapeutic effects
  • Reduction / disappearance of pelvic pain associated with endometriosis.
  • Painless intercourse.
  • Painless menstruation after a course of treatment.
  • Anti-inflammatory effect.
  • Regress with a tendency to scarring endometriotic lesions.
  • In some cases: the restoration of fertility after a course of treatment.

Vizanna does not apply to oral contraceptives. Contraceptive action of dienogest is not enough for reliable protection against unwanted pregnancy.

Instructions for use Vizanna with endometriosis

Before starting treatment with dienogest, you should:

  • Stop taking combined oral contraceptives (COCs).
  • Exclude other types of hormonal contraception.
  • Ensure no pregnancy.

During the reception of Vizanna, if necessary, use barrier methods of contraception (condom).

From which day of the menstrual cycle should be taken Bezanne?
Treatment can begin on ANY day of the menstrual cycle.

How to drink Byzanna with endometriosis?

  • daily,
  • ONE tablet per day, by mouth (put 1 tablet in the mouth and swallow it, you can drink it with water).

What time of the day to take a pill?
Byzanna should be taken at the same time, preferably in the afternoon.

Reception mode Vizanna:

  • endometriosis is treated with dienogest in a continuous manner,
  • The recommended course of treatment is 6 months and longer, but not more than 15 months in a row.

Tablets should be taken every day without interruption, from one package of the drug to another, not paying attention to the appearance of spotting or menstrual discharge from the genitals.

What to do if the next reception of Vizanna is missed?
If you forgot to drink one pill (or several pills, several days in a row) in due time, you should take ONE pill as soon as you remember it. The next day, continue taking the medicine at the usual time, in the usual dose.

How to combine reception of Vizanna with food?
Eating does not affect the effect of the drug. It does not matter when to take a pill: between, before, during or after a meal.
Combining taking the drug with alcohol is highly undesirable and unsafe.

What are the age limits for accepting Wizanna?
Dienogest therapy is allowed from adolescence after menarche (first menstruation) and for women of reproductive age before menopause.
In the "free from menstruation" periods of life (childhood, postmenopause), the treatment of Visanna is inappropriate.

Accepting Vizanna during pregnancy and lactation

If pregnancy occurred during treatment, the drug should be discontinued.

Clinical case:
Patient D. complained of prolonged infertility.
Medical diagnostic laparoscopy was performed.
Confirmed diagnosis of endometriosis grade 3.
In the postoperative period, the patient is prescribed therapy with dienogest (Vizanna).
On the 6th week of taking the drug, a spontaneous pregnancy began. Hormonal treatment was discontinued.
The period of carrying the desired child passed without features, the pregnancy ended in time by natural childbirth (girl, Apgar scale 8-9, weight 3 kg 180 g).

How Byzanna affects menstruation

After 1-2 months of taking the drug in most patients, menstruation disappears - amenorrhea occurs.

Sometimes menstruation "does not come" in the first month of treatment. Sometimes the opposite: the first one or two cycles menstrual bleeding increases, become longer and more abundant, but then (in subsequent cycles) they become impoverished and disappear.

On the background of taking the drug, acyclic menstrual-like or spotting bloody, brown, “black” discharge may appear. This is the physiological response of the “addiction” of the endometrium to drug hormonal stimulation. The situation does not require correction and is resolved independently.

In rare cases, breakthrough bleeding occurs on the background of the reception of the Byzanna. With abundant, prolonged uterine bleeding (more than 7 days without a tendency to decrease), you should contact your doctor.

When do menses recur after Vizanna is canceled?
In 97% of cases, the normal menstrual cycle is restored in 1.5-2 months after completion of the drug.

According to clinical studies, in the experimental group (101 people) in the majority of patients, the first menstruation occurred on the 28-29th day after the end of the reception of Vizanna. All women had monthly periods without pain.

Contraindications to the use of Vizanna

The official prohibitions on accepting Vizanna are the same as those of all progestins. However, not all limitations are confirmed clinically. Therefore, if the patient has risk factors, the appropriateness of the appointment or cancellation of Vizanna in endometriosis is assessed individually.

Strict contraindications:

  • Breast cancer, other hormone-dependent malignant tumors.
  • Hepatitis, uncompensated liver diseases, liver tumors.
  • Thrombophlebitis, thrombosis, confirmed increased tendency to thrombosis.
  • Acute / uncompensated pathology: endocrine, cardiovascular, somatic ...
  • Uterine bleeding for unexplained reasons.
  • Individual intolerance, allergy to any of the components of the drug.
  • Children age before menarche (up to about 12 years).
  • Pregnancy, lactation.
Relative contraindications /
use with caution

(in the presence of the following conditions, Vizanna is assigned / canceled after an individual assessment of the ratio of benefits and possible risks)

  • Atherosclerosis, ischemic disease, another chronic cardiovascular pathology.
  • Heart attack, stroke in the past.
  • Hypertonic disease.
  • Diabetes.
  • Varicose veins
  • Cholestatic jaundice in pregnant women or severe liver disease in the past.
  • Migraine with aura.

General information about the pathology

Adenomyosis is a form of endometriosis.in which the endometrium grows into the uterine cavity, and in some cases beyond its limits. According to statistics, the disease is most often diagnosed in women from 18 to 45 years.

The true cause of the development of adenomyosis today has not been established. But factors that can provoke pathology include:

  • genetic predisposition
  • stress,
  • excessive exercise
  • endocrine system pathologies,
  • hormonal disbalance,
  • disruption of the immune system.

The main symptoms of the disease are: menstrual irregularities, menstrual pain, fatigue. Adenomyosis is treated both in a medical and surgical way.

How does Byzanne affect the foci of adenomyosis?

Drug treatment of adenomyosis includes hormonal medication. One of these drugs is Vizanna, the main component of which is dienogest. This substance has a powerful antiandrogenic effect.

Dienogest with the ability to bind to progesterone receptors in the uterine cavity, thereby enhancing the therapeutic effect, due to which it occurs:

  • reducing the effect of estrogen on the foci of adenomyosis,
  • reduction of adenomyotic foci,
  • a decrease in estrogen concentration and a decrease in its production in the ovaries.

The drug is available in the form of white tablets. After the drug enters the body, dienogest is completely absorbed into the blood, while its maximum concentration occurs after 1, 5 hours. Basically, the metabolism of the active substance occurs in the liver, and the removal of decay products occurs during urination.

The treatment of Visanna with adenomyosis is at least 6 months.. The final term of therapy is determined by the attending physician. The drug is convenient because you can start treatment on absolutely any day of the menstrual cycle.

Opinion of women about the drug

Visanna is a fairly new and modern drug. Among the many reviews from women using the drug to combat adenomyosis, positive prevail.

Ekaterina, 27 years old, Kazan

About a year ago, during a routine inspection, I was diagnosed with adenomyosis. At that time I did not even hear about such a diagnosis, and therefore I was very upset. But thanks to my gynecologist, for whom I have been observing for more than a year. He advised me to the drug Visanna. And now, after 9 months, the disease has receded. At the last control, the ultrasound showed that the adenomyotic foci had practically disappeared.

Margarita, 33 years old, Kislovodsk

I encountered the problem of adenomyosis for the first time 3 months ago. Moreover, my disease was asymptomatic, and I found it when clarifying the causes of my infertility. I was diagnosed with adenomyosis at the first stage, so the treatment of Visanna comes to an end. I really hope that after the control ultrasound, I will be able to plan a pregnancy.

Julia, 35 years old, Moscow

I can definitely say that Byzanna helped me. She took the pill for 4 months and the foci of adenomyosis almost disappeared. True, there is a small nuance; in the first week of taking the drug there was a slight feeling of nausea. But over time, everything went, the whole further course of treatment no longer bothered any side effects.

Christina, 25 years old, Nizhny Novgorod

To begin with, my husband and I, together with 18 years old and, of course, really wanted a child. But for two years I could not get pregnant. Then we decided to undergo an examination and it turned out that I had adenomyosis. Gynecologist advised to carry out treatment of Visanna. And lo and behold, after 7 months, I finally got pregnant. Of course, the drug has its drawbacks, first of all its high cost. In addition, during the treatment I gained some weight. But all these shortcomings seem insignificant, because after getting rid of adenomyosis, I can have children. Therefore, everyone decides for himself. All good health!

Attention! The drug may be prescribed only by a gynecologist. Self-treatment not only does not lead to recovery, but can also provoke a lot of side effects.

General description of the drug

The drug Vizanna is a product of a famous German pharmacological company. It is marketed as tablets, which contain synthetic progestogen as an active substance. This component has a pronounced progestogenic activity, which provides the necessary therapeutic effect when using Vizanna.

Peculiarities of the impact of Vizanna on the woman's body with endometriosis

Endometriosis is a chronic disease associated with the proliferation of endometrial cells outside the uterine lining. It is caused by disturbances in the endocrine and immune system of a woman. Special hormone therapy is used to treat this disease.

Its effectiveness is explained by similar properties of the endometrium and pathological endometrioid tissue. They equally respond to an increase in progesterone concentration in a woman’s blood. It inhibits their growth, which leads to a decrease in the foci of endometriosis.

Action in diagnosed endometriosis

With regular use of Vizanna, there is a significant decrease in the concentration of estrogen in the blood plasma and ovaries. As a result, growth of the pathological foci of endometriosis is suppressed, and over time, their complete atrophy occurs. The components of the Vizanna make it impossible for active cell proliferation, which stops the development of the disease.

This hormonal drug helps with any degree of endometriosis. This is explained by the fact that it acts directly on the mechanism of its development.

The principle of operation of Vizanna in adenomyosis

Adenomyosis is a type of endometriosis. This disease is characterized by the growth of the endometrium in the inner muscular layer of the uterus. Vizann's tablets influence a woman's organism in such a way that the mucous membrane of the reproductive organ is strengthened. This is due to the gestagenic effect of the drug and the normalization of the existing hormonal levels.

Expected therapeutic effects

The use of Vizanna has a positive effect on the functioning of the female reproductive system and significantly improves her well-being. After the start of treatment, patients observe the following therapeutic effects:

  • the disappearance of pain syndrome, which is quite pronounced in endometriosis,
  • normal menstrual cycle
  • abundant monthly discharge disappears,
  • a woman stops complaining about intermenstrual discharge,
  • there are positive changes in the structure of the endometrium,
  • in the presence of infertility after the treatment, the chances of successful conception and gestation increase,
  • normal hormones, which positively affects the well-being of women.

Drug benefits

With endometriosis, Vizanna differs from other hormonal preparations by the following characteristics:

  • high bioavailability of the active components of the drug - more than 90%,
  • Vizanna has a selective effect on endometrial tissue,
  • despite the use of minimal doses of medication, a high therapeutic effect is achieved,
  • after taking the pills, they are quickly eliminated from the body and do not accumulate in the tissues,
  • the drug is not a contraceptive, but it inhibits the onset of ovulation,
  • the constituent components of the Vizanna enter the woman’s body in its active form, so they begin to act instantly,
  • The drug does not belong to the category of anti-estrogens. It is not accompanied by tides, does not disrupt the cardiovascular system,
  • Visanna does not cause the development of signs of masculinization in women - male-type hair growth, weight gain, and increased pressure.

Instructions for use

When using Byzanna for endometriosis, the following instructions should be followed:

  • treatment can begin from any day of the menstrual cycle,
  • it is advisable to take pills at the same time, which provides the best therapeutic effect,
  • if bleeding occurs, you do not need to stop taking Visanna,
  • after completing the package, the next one should be started without interruption in treatment,
  • If you have diarrhea or vomiting for 3 hours after taking the pill, you need to drink an extra dose of medication,
  • Before starting treatment, make sure that you are not pregnant and stop taking oral contraceptives,
  • when you skip the drug on the next day, use his usual dose. Increasing the number of tablets is not necessary
  • in the treatment of endometrial hyperplasia or other gynecological diseases, it is necessary to abandon the use of alcohol and smoking,
  • to prevent unwanted pregnancies while taking Visanna, it is recommended to use barrier methods of contraception,
  • taking pills is allowed regardless of the meal. This does not affect the absorption of active ingredients.

Recommended dosages

To achieve a positive therapeutic effect in endometriosis, the treatment of Byzanna must occur in a continuous mode. The recommended duration of one course is six months. If necessary, treatment can last 15 months (but not longer). Tablets are taken daily, one at a time.If necessary, they are washed down with water.

List of contraindications

Byzanna has the following list of contraindications:

  • the presence of varicose veins with a high risk of developing complications,
  • liver disease,
  • heart failure or arterial blockage of any type,
  • hypertension, which is combined with obesity,
  • the presence of gynecological pathologies, where there is a risk of developing malignant processes,
  • diabetes,
  • headaches.

Side effects

The drug Vizanna can cause the following negative effects:

  • the presence of minor intermenstrual bleeding,
  • severe headaches
  • tenderness and discomfort in the mammary gland,
  • the appearance of acne lesions on the skin of the face,
  • unstable psycho-emotional state,
  • weight gain
  • memory impairment and reduced concentration,
  • reduced sexual desire
  • disruption of the digestive system,
  • pain in the muscles of the legs,
  • the development of candidal colpitis,
  • the appearance of edema.

Usually, all side effects occur at the beginning of the course of treatment. All the negative effects in most cases disappear after a while.

What is diffuse, nodular and diffuse nodular adenomyosis of the uterus?

Diffuse, nodular and diffuse-nodular (mixed) adenomyosis - morphological forms of internal endometriosis of the uterus.

Diffuse form of adenomyosis morphologically represents the presence of blind pockets in the endometrium, penetrating from the uterus to different depths of its layers (up to the formation of fistulas in the pelvic cavity).

The nodular form of adenomyosis is characterized by the penetration of glandular epithelium into the muscular layer of the uterus with the formation of nodes of different size. The nodes, as a rule, are multiple, filled with blood or chocolate-colored liquid, which is formed as a result of the functioning of the endometrial glands in accordance with the rhythm of menstrual bleeding.

Most often, endometriotic nodes have a dense texture, since connective tissue grows around them. Such nodes resemble benign encapsulated formations, but endometrial cells may also be located outside the capsule-like connective tissue growths.

The mixed knotty-diffuse form is morphologically represented by both types of elements.

On what grounds is determined by the degree of adenomyosis of the uterus?

What is adenomyosis of the uterus 1, 2, 3 and 4 degrees?

Classification of adenomyosis by the degree of prevalence is not international, but it is quite convenient, and therefore it is often found in the domestic literature, and is carried out in practice.

The severity of this classification is determined by the depth of penetration of endometrial cells into the underlying layers of the uterus (used exclusively in relation to the diffuse form of adenomyosis of the uterine body).

I. Diffuse growths of endometrial cells in the submucosal layer of the uterus.

Ii. The pathological process penetrated the muscle layer of the uterus, but captured no more than half of this layer.

Iii. The muscle layer is involved in the pathological process more than half.

Iv. Growth of endometrial cells outside the muscle layer, in the serous membrane of the uterus, with a further transition to the peritoneum and involvement of the pelvic organs in the process.

What is the danger of adenomyosis (endometriosis)?

Endometriosis is considered benign hyperplasia (pathological proliferation of tissue), since endometrial cells transferred to other organs and tissues retain their genetic structure. However, signs such as the ability to germinate in other organs, the tendency to resettlement throughout the body and resistance to external influences - it is related to malignant tumors.

The word "benign" also refers to the prognosis of the disease - it goes on for years and decades, as a rule, without leading to a severe depletion of the body and death. However, as in the case of malignant hyperplasia (cancer. Sarcoma, etc.), adenomyosis (endometriosis) is difficult to treat conservatively, and surgery for this pathology is much more voluminous than in the case of benign tumors, since it is difficult to determine border between diseased and healthy tissue.

The most frequent complication of adenomyosis is due to the fact that endometrial cells functioning in accordance with the monthly cycle lead to heavy bleeding, which is fraught with the development of acute and / or chronic anemia. In some cases, patients have to be hospitalized, and even operated urgently for life-threatening bleeding.

Adenomyosis is prone to spreading the process to other organs and tissues, which leads to systemic lesions. With extragenital arrangement of endometrial cells, a number of complications are possible, requiring emergency medical intervention (intestinal obstruction in the endometriosis of the gastrointestinal tract, hemothorax (filling the pleural cavity with blood) in endometriosis of the lung, etc.).

And finally, another danger of endometriosis in general, and adenomyosis in particular, is the threat of a malignant genetic transformation of the migrated cells. Such a transformation is very real, since any hyperplasia has a more or less pronounced tendency to malignancy, and at the new site endometrial cells are forced to exist in extremely unfavorable conditions.

How many women suffer from adenomyosis?

The prevalence of endometriosis is the third among gynecological diseases (after inflammatory lesions of the appendages and uterine fibroids).

The incidence of endometriosis is about 20-90% (according to various sources). Such a spread of digital data should not cause suspicion. The fact is that many researchers contribute to these numbers and subclinical (asymptomatic) forms of the disease. According to clinical data, asymptomatic endometriosis accounts for up to 45% of all cases of pathology, and is detected in a study of women seeking help due to infertility. Since endometriosis does not lead to infertility in all cases, the number of women with endometriosis can only be guessed at. Hence the inaccuracy of the figures on the prevalence of pathology.

Endometriosis is most common in women of reproductive age, but in some cases it is diagnosed in adolescents, as well as in women in menopause. taking hormone replacement therapy. Previously it was thought that the peak of the incidence was in late reproductive age and premenopause, but there were works that disprove this statement.

In recent decades, there has been a marked increase in the incidence of endometriosis. This is explained, on the one hand, by the violation of the immunological status of the population under the influence of many factors (environmental problems, stresses, etc.), and on the other, by the introduction of the latest diagnostic methods. sharply increased detection of low-grade and asymptomatic forms (laparoscopy, NMR tomography, transvaginal ultrasound scanning).

What causes the development of adenomyosis?

Unfortunately, the causes and the main mechanisms of development of endometriosis (adenomyosis) are currently not fully understood.

With confidence we can only say that endometriosis is a hormone-dependent disease, the development of which is promoted by impaired activity of the immune system.

Risk factors for adenomyosis include:

  • unfavorable heredity in endometriosis, as well as in benign and malignant tumors of the female genitalia,
  • too early or late onset of menstruation,
  • late onset of sexual activity
  • late childbirth,
  • complicated childbirth,
  • obesity
  • various manipulations on the uterus (abortion. diagnostic curettage),
  • use of intrauterine device,
  • use of oral contraceptives
  • inflammatory diseases of the uterus and appendages, dysfunctional bleeding, especially if there have been surgical interventions or / and long-term hormone therapy,
  • the presence of systemic extragenital diseases (hypertension, diseases of the gastrointestinal tract),
  • frequent infectious diseases, allergic reactions, indicating a violation of the functions of the immune system,

  • low socioeconomic status
  • hard physical labor
  • stresses, sedentary lifestyle,
  • living in an ecologically unfavorable region.

    Symptoms of uterine adenomyosis

    The main and pathognomic (characteristic only for this disease) symptom of adenomyosis are abundant and / or prolonged menstrual bleeding, leading to secondary iron deficiency anemia.

    Anemia, in turn, is manifested by the following symptoms:

  • weakness,
  • drowsiness
  • susceptibility to various infectious diseases,
  • pallor of the skin and visible mucous membranes,
  • in severe cases, shortness of breath with little exertion,
  • dizziness ,
  • a sharp decline in performance and ability to adequately assess their own condition.

    Pathognomic for adenomyosis also includes the appearance of brown spotting 2-3 days before the onset of menstruation, and 2-3 days after it.

    With common forms of adenomyosis, metrorrhagia can develop - uterine bleeding. occurring in the middle of the menstrual cycle.

    Another characteristic sign of adenomyosis is pain syndrome that occurs a few days before the onset of menstruation and, as a rule, disappears 2-3 days after its onset (dysmenorrhea or algomenorrhea).

    The nature and severity of pain depends on the localization process. Especially strong pain syndrome is observed with the defeat of the isthmus of the uterus, as well as in case of widespread adenomyosis with the development of adhesions.

    Adenomyosis is often found in the presence of such pathology as the additional horn of the uterus, with which the clinic may resemble an acute abdomen with endometriosis (menstrual blood is thrown into the pelvic cavity and causes symptoms of peritonitis).

    By the irradiation of pain, it is often possible to establish the localization of the pathological process. So, with the defeat of the uterus, the pain gives to the corresponding groin, and with the defeat of the isthmus - in the vagina or rectum.

    Another characteristic symptom of adenomyosis is soreness during intercourse, especially on the eve of menstruation (most common with lesions of the isthmus of the uterus).

    At clinical examination of patients with adenomyosis, an increase in the uterus is determined, especially pronounced before menstruation and in the first days of the menstrual cycle. For the diffuse form is characterized by "spherical" uterus. When nodular adenomyosis is sometimes possible to probe nodes.

    It should be noted that the severity of symptoms of adenomyosis to a certain extent depends on the extent of the process. So, diffuse adenomyosis of 1 degree is an accidental finding when conducting various examinations, and is asymptomatic. However, in diffuse adenomyosis of 2 and 3 degrees, as well as in the nodular form of adenomyosis, the severity of clinical symptoms does not always coincide with the degree of prevalence of the process and the magnitude of the nodes.

    How does adenomyosis occur in conjunction with uterine myoma?

    The probability of combining adenomyosis with uterine myoma is very high (up to 85%, according to some authors), which is explained by similar mechanisms of development of these pathologies.

    An increase in the uterus in such cases usually corresponds to the size of the fibroids. The size of the organ does not return to normal after menstruation, as is the case with isolated diffuse adenomyosis.

    However, the remaining symptoms of adenomyosis when combined with myoma do not undergo pronounced changes. The exception is uterine fibroids with a submucosal arrangement of nodes; in such cases, abundant acyclic uterine bleeding is observed.

    The combination of adenomyosis with uterine myoma is poorly amenable to conservative treatment, therefore it is with this combination of pathologies that patients are most often advised to decide on a hysterectomy (removal of the uterus).

    Signs of a combination of adenomyosis with ovarian endometriosis

    Adenomyosis is often combined with ovarian endometriosis, which is explained by the proliferation of the process from the uterus. Many researchers suggest that the formation of endometrial growths on the ovaries is associated with the throwing of menstrual blood through the fallopian tubes, containing proliferative live endometrial cells.

    The prevalence of the process there are four degrees of ovarian endometriosis:

    I. Point foci of endometriosis on the surface of the ovary and on the peritoneum, in the recess between the uterus and rectum.

    Ii. One-sided endometrial cyst of no more than 6 cm in size, adhesions in the uterine appendages without intestinal involvement.

    Iii. Bilateral endometrial cysts up to 6 cm in size, pronounced adhesions with intestinal involvement.

    Iv. Large bilateral cysts, the transition process on the bladder and colon, a common adhesive process.

    With the spread of endometriosis from the uterus to the ovaries, a whole group of symptoms joins the signs of adenomyosis.

    First of all, the pain syndrome is transformed. Unlike adenomyosis, pain has a constant, periodically increasing nature. The maximum increase in pain is characteristic of the onset of menstruation and the period of ovulation (the release of a mature egg from the follicle in the middle of the menstrual cycle). Pain in endometriosis of the ovary are localized in the lower abdomen, in the projection of the uterus, have a aching or pulling character, give to the lumbar region, the sacrum, in the rectum.

    For adenomyosis, combined with endometriosis of the ovary, more characteristic pronounced premenstrual syndrome. often accompanied by nausea. vomiting. cooling of the extremities, a sharp decline in working ability. In the first days of menstruation, subfebrile condition is possible, a change in laboratory parameters of the complete blood count (an increase in the number of leukocytes and ESR).

    With the development of adhesions may cause disruption of the bowel and bladder (constipation. Frequent and painful urination).

    During clinical examination, palpation of the appendages reveals their increase and tenderness, sometimes it is possible to probe the ovarian endometriosis cysts. Cysts are palpated, as a rule, when the size is more than 6 cm from the side and / or posterior to the uterus, as tumor-like formations of a densely elastic consistency, immobile due to the development of adhesions, sharply painful, especially on the eve and during menstruation.

    For accurate diagnosis, the same types of studies are needed as in isolated adenomyosis.

    Based on what studies are diagnosed with adenomyosis?

    Of paramount importance for proper diagnosis is the collection of anamnesis with the determination of the existence of risk factors in this patient (unfavorable heredity, operative manipulation of the uterus, certain physical diseases, etc.) and analysis of complaints (abundant and / or prolonged menstruation accompanied by pronounced pain, pain during intercourse, symptoms of anemia).

    Then the doctor performs a physical examination (examination on the gynecological chair), during which, in the case of adenomyosis, a spherical uterus enlargement corresponding to 8-10 weeks of pregnancy (rarely more) is usually detected. Inspection is best carried out on the eve of menstruation, because at this time an increase in the uterus is most noticeable. When the nodular form of adenomyosis is often possible to probe the nodes or tuberosity of the uterus.

    As a rule, careful collection of anamnesis with analysis of the obtained data, supplemented by physical examination, makes it possible to correctly make a preliminary diagnosis of internal endometriosis of the uterus (adenomyosis).

    To clarify the diagnosis, in particular to determine the localization and extent of the process, additional instrumental studies are carried out to resolve the issue of further tactics of treatment of the patient.

    The gold standard of the study for suspected adenomyosis is an ultrasound scan. In addition, such survey methods as nuclear magnetic resonance are often used. hysterosalpingography and hysteroscopy.

    What are the signs of adenomyosis?

    Among all types of echography (ultrasound), transvaginal ultrasound scanning is most informative in adenomyosis. The accuracy of diagnosis with this method of examination exceeds 90%.

    If adenomyosis is suspected, it is best to perform an echography on the eve of menstruation (on the 23-25th days of the cycle).

    Over the long years of development of ultrasound diagnostics, the following pathognomical echo signs of internal endometriosis (adenomyosis) of the uterus have become generally recognized:

    1. An increase in the anteroposterior size of the uterus, with the result that the organ acquires a spherical shape.

    2. Enlarged uterus up to 6 weeks of pregnancy and more.

    3. Asymmetry of wall thickness.

    4. The appearance on the eve of menstruation in the muscular layer of the uterus cystic cavities with dimensions of 3-5 mm and more.

    What treatment is prescribed for uterine adenomyosis?

    Adenomyosis is not the suffering of a separate organ, but a chronic systemic illness of the body.Therefore, the treatment of pathology requires a purely individual approach, taking into account all the mechanisms of the onset and development of the disease in a particular patient.

    Thus, when choosing a method of therapy, many factors are taken into account, first of all:

  • the patient's age, and her desire to have children in the future,
  • localization and prevalence of the pathological process,
  • the severity of the clinical picture and the risk of complications,
  • general condition of the body (the presence of concomitant diseases, the state of the immune system, etc.),
  • duration of adenomyosis.

    All medical measures to combat adenomyosis can be classified as follows:

    I. Surgery:

    Ii. Conservative treatment:

  • hormone therapy
  • non-specific anti-inflammatory therapy,
  • sedatives (sedatives),
  • vitamin therapy,
  • maintaining liver function,
  • elimination of anemia
  • immunomodulators,
  • absorbable therapy
  • physiotherapy.

    Iii. Combined treatment.

    The general algorithm for treating patients with adenomyosis is the following: first of all, conservative treatment is prescribed, and if it is ineffective, or if there are contraindications to the use of hormonal drugs, they turn to surgical methods of treatment.

    In recent years, organ-preserving endoscopic operations have been successfully used to treat patients of reproductive age. The main indications for their conduct are:

  • adenomyosis in combination with endometrial hyperplasia,
  • functioning endometrial ovarian cysts (more than 5 cm in diameter),
  • suppuration of uterus appendages affected by endometriosis,
  • adhesions in the ampulla of the fallopian tubes (the main cause of infertility in endometriosis),
  • the ineffectiveness of hormone therapy (there is no positive dynamics in the treatment of hormonal drugs for more than 3 months),
  • the presence of somatic diseases, which are contraindications to long-term hormonal therapy (varicose veins and thrombophlebitis, severe liver disease, migraine, depressive states, epilepsy, cerebral circulation disorders, obesity, diabetes mellitus, hypertension, etc.).

    Organ-preserving operations are not a radical method of treatment, since it is impossible to isolate all the foci of endometriosis, however, they are the method of choice for women who want to restore and / or maintain fertility.

    Radical surgery with removal of the uterus and / or ovaries is performed if the following indications are present:

  • progressive course of the disease in women over 40,
  • lack of effect from the combined treatment with carrying out organ-preserving operations,
  • a combination of a nodular form of adenomyosis or diffuse adenomyosis of grade 3 with uterine myoma,
  • the threat of malignant transformation.

    Is it possible to cure adenomyosis?

    Adenomyosis - a disease with a chronically relapsing course. Relapse statistics after successful non-radical treatment (conservative therapy, organ-preserving operations) is about 20% per year. After five years, the number of relapses reaches 74%.

    The longest effect is observed with the combined use of surgical (organ-sparing operations) and conservative (hormonal therapy) methods of treatment of adenomyosis, but in most cases relapses are nevertheless unavoidable.

    The prognosis of premenopausal women is somewhat better, since with the physiological extinction of ovarian function, the activity of the process subsides.

    In patients undergoing radical surgery (removal of the uterus and ovaries), the process does not resume.

    Can I get pregnant with uterine adenomyosis?

    Adenomyosis is the second leading cause of female infertility after inflammatory diseases of the female genital tract. And if, moreover, it is considered that part of the chronically worsening adnexitis (inflammatory processes in the ovaries) is caused not by an infectious process, but by internal endometriosis, then the connection between adenomyosis and infertility becomes obvious.

    According to statistical studies of various authors, infertility in adenomyosis is diagnosed in every third or second case, or even more often (according to some data, the level of infertility among patients with adenomyosis reaches 60-80%).

    The mechanisms of infertility in adenomyosis are different in different patients, and, consequently, the prognosis and treatment tactics will be different.

    We list the most common causes of infertility in patients with internal endometriosis of the uterus (in decreasing order of observation frequency):

    1. Violation of the transport function of the fallopian tubes due to adhesions, or a decrease in their motor activity, so that the egg can not get from the ovary into the uterus.

    2. Pathological changes in the hormonal sphere that prevent ovulation (the maturation of the egg and its release from the follicle). Some authors consider this reason to be the main cause of infertility in adenomyosis.

    3. Autoimmune reactions leading to deactivation of sperm in the uterus, as well as preventing implantation of a fertilized egg and the further development of the embryo.

    4. Early termination of pregnancy due to increased contractility of the myometrium caused by inflammatory events in the muscle layer of the uterus.

    5. Soreness during sexual intercourse, making it difficult to have regular sex life.

    Often infertility with adenomyosis can be caused by several reasons at once, therefore, long-term complex treatment is necessary to restore reproductive function. The success of therapy strongly depends on the duration of the infertility period. So, the best results are obtained if its duration does not exceed 3 years.

    Thus, adenomyosis often leads to infertility, however, timely complex treatment gives chances of restoring the ability to conceive.

    Adenomyosis and pregnancy. Is there a chance to make and give birth to a healthy

    To date, collected a lot of material on the course of pregnancy. childbirth and the postpartum period in women suffering from internal endometriosis of the uterus (adenomyosis). General conclusions from numerous studies can be summarized in the following positions:

    1. In women with adenomyosis, the incidence of infertility is increased (from 40 to 80% according to various sources), but timely comprehensive treatment of endometriosis in most cases leads to the restoration of fertility.

    2. A frequent complication in women with adenomyosis is the threat of premature termination of pregnancy. However, adequate therapy in most cases can stabilize the condition. The treatment is carried out according to the general standard scheme, as well as in women who do not suffer from adenomyosis.

    3. Artificial or spontaneous termination of pregnancy leads to a relapse or exacerbation of adenomyosis with subsequent accelerated development of the pathological process, so you should, if possible, strive to preserve the pregnancy.

    4. Most women with adenomyosis pass safely, but there is an increased tendency to uterine bleeding in the aftermath and the early postpartum period, so the possibility of developing these complications should be considered.

    5. After childbirth with the restoration of menstrual function, the process can be activated, but it is always lower than in the case of artificial or spontaneous abortion.

    6. After artificial and spontaneous abortions, as well as after childbirth with the restoration of menstrual function, patients with a history of adenomyosis need anti-relapse treatment (hormone therapy, immunomodulators, antioxidants, etc.).

    What are the popular methods of treatment of internal endometriosis

    (adenomyosis) uterus? Is it possible to cure folk adenomyosis

    There are many different ways of folk treatment of adenomyosis, some of them are recognized by official medicine, and can be included in complex treatment of pathology.

    However, the network and in the real quasi-medical literature contain many useless and even extremely harmful advice, so before using any of the popular recipes for the treatment of adenomyosis, you should consult with your doctor. In no case should you replace the treatment prescribed by a doctor with traditional methods.

    Adenomyosis is a disease prone to relapse, so it is very difficult to completely cure it, both with the help of official and with the help of traditional medicine.

    However, official medicine guarantees that a comprehensive treatment of internal endometriosis of the uterus can improve the quality of life, suspend the process and minimize the risk of complications. With the timely start of adequate therapy, the chances of preserving reproductive function are quite high.

    Therefore, in case of adenomyosis, one should first of all seek the help of official medicine. You can use traditional medicine approved traditional methods of treating adenomyosis after consulting with your doctor.

    Before use, you should consult with a specialist.

    What drugs are used to treat adenomyosis

    Adenomyosis is one of the most common ailments in women. This disease is characterized by pathological proliferation of endometrial cells, which adversely affects the reproductive system and overall women's health.

    Adenomyosis has four stages of development. each of which is distinguished by the extensive damage of the genital organs and the depth of penetration of the expanding cells into the tissue. However, the diagnosis of adenomyosis is not a sentence, since this ailment is benign and very rarely turns into oncology.

    Nowadays, adenomyosis is well treated and in order for the pathology to stop its rapid development, it is enough to choose the right medical therapy. In addition, medication allows a woman to become pregnant independently and take out a healthy child.

    When therapy is needed

    Treatment of adenomyosis is prescribed for each patient individually. After the diagnosis is made by the doctor, the most appropriate drug is selected, which in the course of therapy stops the uncontrolled growth of cells.

    However, adenomyosis does not always need treatment.

    So, drug therapy is necessary only if the woman has the following complaints:

  • disruptions in the cycle, characterized by delayed menstruation,
  • painful and too heavy periods,
  • pain in the lower abdomen in the middle of the cycle and before the onset of menstruation,
  • pronounced symptoms of adenomyosis. especially for women of childbearing age
  • problems with conception.

    Preparations for the treatment are selected in accordance with some factors that must always be considered for successful treatment, namely:

  • the presence of contraindications to the existing components of the drug,
  • age of the patient
  • Does the history of psychological diseases
  • the presence of additional diseases such as hyperplasia, adhesions of the fallopian tubes, scarring, etc.

    In addition, prescribing medications, should consider whether or not the patient plans to become a mother at the time of going to the doctor.

    Types of drugs for treatment

    The most effective treatment for adenomyosis are hormonal drugs. It is these drugs that have numerous positive reviews from doctors, as they help to eliminate the pathological proliferation of cells in the shortest possible time and provide an improvement in reproductive function.

    The main hormonal agents in the treatment of adenomyosis are:

  • drugs that contain synthetically reduced estrogen,
  • hormonal based on progesterone,
  • androgens
  • medications with hormone gonadotropin or similar substances.

    Estrogen-based hormonal drugs help mimic pregnancy. They are assigned to those patients who plan to conceive immediately after the treatment of adenomyosis. In addition, estradiol is actively involved in the relief of pathological proliferation of cells in the area of ​​the endometrium and reduces the painful symptoms in the lower abdomen.

    Progesterone is a hormone secreted by the ovaries. Treatment of adenomyosis with progestin drugs helps restore the cycle and normalize the ovulatory processes that a woman needs to get pregnant.

    Therapy of adenomyosis, including androgen-based drugs, is the complete cessation of menstruation. This normalizes the state of the uterus, suppresses monthly disruptions in the hormonal system and stops the spread of pathological foci.

    Gonadotropin allows you to optimize the production of estradiol, which suppresses the uncontrolled growth of cells. But such drugs are used infrequently, as they affect the development of osteoporosis.

    A popular and fairly effective drug for adenomyosis is Janine. He is known by many women, as these pills are often used as contraception.

    Its plus is that it has a minimal list of side effects, since the hormones that make up it are contained in very small quantities. In addition, the drug Janine is easily absorbed by the body, so you do not need to increase its dosage.

    The main Janine is:

    The first hormone inhibits the pathological proliferation of endometrial cells, which suppresses the development of adenomyosis until it disappears completely. Estrogen, in turn, activates the growth of the ovarian follicle, which contributes to ovulation.

    The hormonal drug Duphaston contains an artificial analogue of natural progesterone, which is secreted in a woman's body during ovulation by the yellow body of the ovary.

    It is because of insufficient release of progesterone that such a disease as adenomyosis often develops. Therefore, Duphaston therapy is prescribed in most cases of the disease and is quite effective.

    Duphaston belongs to the hormonal means of the new generation, therefore it has a minimum of side effects and is rather well tolerated. In addition, progesterone treatment gives not only positive results, but also significantly resistant. The reappearance of adenomyosis after Duphaston therapy is quite rare.

    Means Byzanna with adenomyosis is assigned quite often. The drug has a firming effect on the uterine mucosa and has a gestagenic effect.

    The hormone dienogest, which is part of Vizann, reduces the intensity of reproduction of endometrial cells of the uterus by inhibiting the production of estrogen.

    If during treatment with this drug to adhere to all the recommendations of the attending physician, then you can quickly stop the further development of the disease and prevent the emergence of new foci of pathological proliferation of endometrial cells.

    To consolidate a positive result and prevent recurrence of Bezanne adenomyosis, it is necessary to take at least six months, but always under the supervision of a specialist.

    Orgametril

    The basis of Orgametril is the hormone linestrenol. It tends to suppress ovulation and delay menstruation. With adenomyosis, this drug is prescribed to normalize the production of progesterone, the lack of which leads to impaired cellular growth in the uterine cavity.

    Orgametril is taken for adenomyosis in a certain period of the month, namely from the 16th to the 25th day of the cycle, and is prescribed only if the appearance of the disease is affected by the lack of the hormone progesterone.

    Orgametril should be taken at least 6 months. It is with long-term treatment with linestrenol that the complete disappearance of the pathological foci of endometriotic cells can be achieved and the reproductive function can be improved.

    However, treatment with this tool should be strictly under the supervision of a physician. The fact is that Orgametril has a fairly large list of side effects and contraindications.

    Clayra's hormonal agent is often used in gynecology for the treatment of adenomyosis. It effectively eliminates further uncontrolled reproduction of endometrial cells and inhibits activity in the existing foci.

    Clayra contains two hormones: dienogest, which is an analogue of organic progesterone, and a large amount of estrogen.

    Due to the latter, the treatment of adenomyosis with this drug should be carried out with caution and only under the supervision of a gynecologist. The fact is that estrogen often provokes the pathological proliferation of endometrial cells, so before using it you must make sure that it is not the original cause of the illness.

    Kleira is appointed at the initial stages of adenomyosis development, and the minimum period of his admission is 6 months.

    Mirena is an intrauterine hormonal coil that is inserted into the uterine cavity to prevent unwanted pregnancy.

    Spiral Mirena contains a large amount of the hormone levonorgestrel, which is released daily from the device into the uterine cavity in small doses. Its advantage is that it acts exclusively in the uterus, which reduces the likelihood of suppression of the ovaries and reduces the risk of side effects.

    Устанавливается Мирена не только с целью контрацепции, но и для терапевтического лечения некоторых недугов. Так, гормональная спираль часто используется для лечения миомы матки и аденомиоза.

    Показанием к установке спирали Мирена являются:

  • болезненная менструация,
  • обильные месячные,
  • intermenstrual smearing periodic discharge.

    Mirena is appointed exclusively by the gynecologist, the same applies to her installation. In no case should you try to put the helix into the uterus.

    The drug Silhouette is an analogue of such a hormonal agent, as Jeanine. It contains two hormones, one of which suppresses the development of pathological foci, and the second promotes the maturation of the follicle, which ensures timely ovulation.

    Silhouette in adenomyosis is often used as an analogue of more expensive drugs. But, despite its lower cost, it is quite effective and has a minimum of side effects, as it belongs to the medicines of the new generation.

    The minimum course of therapy with Silden for adenomyosis is six months. The maximum is chosen individually, depending on the degree of development of the disease, the age of the patient and concomitant diseases.

    Regulon is better known among women as a means of contraception.

    It contains:

  • 30 mcg ethinyl estradiol,
  • 150 mcg dizegestrel.

    In case of adenomyosis, Regulon is prescribed if the ailment was triggered by insufficient production of progesterone. It normalizes the function of the corpus luteum and ensures long-term remission after the disease has receded.

    The main function of Zoladex in the treatment of adenomyosis is to give the reproductive system a break from constant problems with hormones that cause problems with the cycle and menstruation.

    Zoladex suppresses the production of natural estrogen, which stops the further growth of endometrial cells and prevents the further development of foci.

    However, treatment with this tool should be carried out with caution, since its long-term use can cause a number of undesirable effects.

    Indole Forte

    Indole Forte belongs to herbal preparations, the reception of which helps to improve the production of the hormone progesterone and normalize the work of the entire reproductive system.

    This tool is prescribed not only for adenomyosis, but for any hyperplastic processes in the tissues and organs of the female reproductive system.

    Indole Forte suppresses the production of hormones that provoke the pathological proliferation of cells in the uterus and mammary glands.

    The hormone drug GES in the treatment of adenomyosis is prescribed to stop the pathological proliferation of cells and normalize the menstrual cycle due to artificially synthesized hormones.

    The drug belongs to the hormonal pills of the new generation, so it is quite easily tolerated by patients, and side effects during its long-term use are rarely observed. However, this does not mean that it can be drunk without a prescription. Jess, like all hormonal drugs, has a number of contraindications, which should be taken seriously.

    Utrozhestan

    Therapy for adenomyosis Utrozhestanom is recommended with insufficient production of the hormone progesterone. In addition, this drug is often prescribed for conception, as it stimulates the synthesis of normal secretion of the endometrium and improves the function of the corpus luteum of the ovary.

    In addition, Utrozhestan is used to prevent miscarriage in all terms of gestation, which is quite often seen in women with adenomyosis and endometriosis in history.

    Candles Diklovit with adenomyosis are assigned to eliminate pain. In addition, they are excellent help with too heavy periods, which, with the pathological growth of endometrial cells, always bother women.

    In addition, Diklovit is recommended for use in the advanced form of adenomyosis, which is aggravated by the inflammatory process in endometrial tissues.

    The drug not only quickly relieves pain in the lower abdomen, but also helps to eliminate inflammation and edema itself.

    At the initial stages of endometriosis development, doctors often recommend that patients take vitamin E or include products containing this component that is useful for women's health.

    Vitamin E contributes to the normal production of natural progesterone, and also normalizes the growth of endometrial cells.

    In some cases, vitamin E is prescribed for more advanced adenomyosis. Its use in parallel with medical treatment helps to resolve the pathological multiplication of cells faster and stop the further development of the disease.

    Homeopathy

    Treatment of adenomyosis with homeopathy is carried out with non-hormonal drugs, which are selected individually for each patient after a thorough diagnosis.

    Regarding the effectiveness of such treatment, gynecologists and homeopathic doctors have been arguing for more than a year, however, it, like hormones, is used quite often. Usually, preparations of Western Thuja (Thuja), Klopogon Kistomenny (Actaea racemosa) are used.

    Most often, women who have contraindications to taking hormones or who are afraid to drink hormonal contraceptives for a long time are turning to homeopathy. After all, as you know, they have a fairly extensive list of side effects, including diabetes, thrombophlebitis and other dangerous diseases.

    Causes of adenomyosis

    There are several theories of the appearance of adenomyosis, but none of them have been proven. This hormone-dependent state and sex hormones play a significant role in the development of this disease. During menopause and menopause, the level of hormones decreases, this explains the decrease and disappearance of symptoms associated with adenomyosis.

    Types of adenomyosis

    Types (forms) of adenomyosis are distinguished depending on the degree of distribution and invasion of heterotopies.

  • Focal endometriosis. It is spoken of if the endometrioid tissue forms islets in the uterus muscle. Often this form is asymptomatic.
  • Nodular form of adenomyosis. Individual nodes are located in the uterus muscle, in their form and appearance they resemble myomatous nodes, therefore they are called adenomyomas.
  • Diffuse form of adenomyosis. In this form, the endometrial tissue uniformly germinates the uterus muscle, its entire layer.
  • Combined form of adenomyosis. In the case when there are several forms of adenomyosis.

    Degrees of adenomyosis

    There are several degrees of adenomyosis. This gradation depends on how deeply adenomyosis penetrates the uterus.

    1. Endometrioid tissue in the submucosal layer

    2. Endometrioid tissue affects 1/3 of the thickness of the uterus muscles

    3. Endometrioid tissue invades muscle by ½ thickness.

    4. Deep damage when endometriotic tissue invades the entire thickness of the uterus.

    Manifestations of endometriosis

    In some cases, adenomyosis is asymptomatic and is detected by chance during examination. In other cases, the symptoms of adenomyosis are as follows:

  • Abundant prolonged menstruation, with clots, the duration of which is more than a week.
  • Intermenstrual brown discharge.
  • Severe pain during menstruation (algomenorrhea) and outside it. The nature of pain skvakoobrazny or cutting.
  • Dyspareunia (painful intercourse).
  • The uterus increases by 2-3 times

    What are the effects of adenomyosis?

    Quality of life is worsening due to pain. Abundant blood loss can lead to anemization, which requires treatment. Adenomyosis itself is not dangerous for life, but in some (severe cases), when endometriotic tissue germinates in the deep layers, the woman becomes disabled, and constant pain leads to depressive states, depressed mood, psychological problems.

    Pregnancy with adenomyosis

    It is believed that adenomyosis can cause infertility, but this fact has not been proven. There is an opinion that infertility is not associated with adenomyosis, but with endometriosis often accompanying it. If adenomyosis is accompanied by a lack of pregnancy for a specific time, a thorough examination and subsequent treatment will be required.

    How is the diagnosis of adenomyosis

    If a woman has at least one of the above listed symptoms, which can be suspected of adenomyosis, then it is necessary to consult a gynecologist as soon as possible. The most difficult thing in the diagnosis of adenomyosis is that there are still no exact methods for diagnosing this disease. The only reliable method is the histological examination of the uterus removed. But this is certainly not a solution. Therefore, alternative methods are used to diagnose adenomyosis. These include MRI, ultrasound, biopsy, hysteroscopy, metrosalpingography.

    Diagnosis of adenomyosis with ultrasound of the pelvic organs

    Ultrasound - a highly informative diagnostic method, but it is not final in the diagnosis. The main signs of adenomyosis:

  • Enlarged uterus size
  • Changing the shape of the uterus
  • Structure heterogeneity
  • Detection of small cysts in the myometrium
  • Uterus muscle thickening
  • Hysteroscopy in the diagnosis of adenomyosis

    The cause of uterine bleeding can be polyps, fibroids, endometrial hyperplasia, uterine neoplasia. To exclude these pathological processes will help hysteroscopy. During hysteroscopy, the doctor may take a biopsy. During hysteroscopy, endometrioid heterotopies are visualized, which allows a diagnosis to be made with high confidence.

    Menopause adenomyosis

    In the perimenopausal age of 45-55 years, adenomyosis is diagnosed quite often. If it is not pronounced and does not cause major problems for a woman, then he is not subject to therapy. If there are symptoms, for example, irregular menstruation, pain in the abdomen, analgesics may be prescribed, COC. If adenomyosis is so pronounced that it affects a woman’s quality of life, then surgical treatment may be the only salvation.

    Surgical treatment of adenomyosis

    The operation for adenomyosis is recommended in the following situations:

    • Metrorrhagia (severe uterine bleeding)
    • No plans for the birth of children
    • The combination of adenomyosis with uterine myoma large sizes
    • The combination of adenomyosis with hyperplastic changes in the endometrium or pathology of the cervix

    Clinic of adenomyosis of 1 degree and other stages of the disease

    However, its growth can be directed not into the cavity, but into the body of the uterus, into its muscular layer (myometrium). So develops adenomyosis of 1 degree, after which, if untreated, stage 2 of the disease is observed. In total there are 4 stages of development of pathology, and each following carries more and more complications for a woman’s health.

    Varieties of the disease

    In fact, adenomyosis is a type of endometriosis. Pathology is characteristic of women of any age. The disease is divided into 3 forms, each of them is found in a certain age group of patients. For example, women in premenopause more often suffer from a focal type of the disease. In young girls, women of childbearing age, there are mainly diffuse and nodular adenomyosis.

    Main symptom

    The disease is manifested by severe pelvic pain. This symptom can be of different intensity, but it is always present. Other signs of pathology are often absent, and this causes a late visit to the gynecologist. This situation is characterized by certain risks, since adenomyosis gynecology is considered a precancerous disease.

    The cunning of the disease is that it affects both adolescent girls and women of late age. However, many stages of the development of the disease have not yet been studied, and they are similar to other pathologies.

    Adenomyosis in ICD 10

    In the system of the international classification of diseases ICD 10, pathology is in the class of endometriosis. Has code N80.0 along with endometriosis. This subclass of ICD 10 is included in the class of non-inflammatory diseases of the female genital organs. The fact that in ICD 10 these 2 pathologies are not separated by code, speaks of their comparability.

    In case of adenomyosis, the tissue expands in the other direction, into the muscle layer, but has the same structure as in classical endometriosis of the uterus. It should be noted that the main role of ICD 10 is statistical. The document is normative, it provides a common standard of approaches to the definition of diseases.

    According to ICD 10, the methodological approaches to adenomyosis and endometriosis are the same. Endometriosis of other organs in ICD 10 has different codes, but they belong to the same class N80.

    Extent of the disease

    At superficial growth of the endometrium 1 degree of the disease is diagnosed. If the foci deepen into the myometrium, adenomyosis of grade 2 is observed, and there is no deep epithelium growing into the muscle layer. The number of foci is more than one, but not many. The second stage is characterized by intense pain, for the treatment of which more potent drugs are required than with grade 1 pathology.

    Pain relief

    The primary treatment of adenomyosis is aimed at relieving pain syndrome. Hormone therapy is also used, because disorders in the growth of the endometrium are always associated with a failure of the hormonal background. The pain is relieved by gradually increasing the dose of the drug or using stronger medicines. The dose is prescribed by the doctor, and the following factors are taken into account:

    - the patient's tolerance of substances from which the drug is produced

    - the degree of analgesic effect, as well as the ability to apply for a long time.

    Restore hormonal levels

    Hormonal treatment is carried out with estrogen-progestin drugs. For example: Non-ovlon daily 1 table. for 21 days. A break is made for periods, the duration is 7 days. Reception time is 3 months.

    Then take a choice: Marvelon, Rigevidon (low-dose hormonal drugs in a similar pattern: 21 days of intake, 7-day break). Diane-35, Janine or Regulon is also written to restore the menstrual cycle. It should be noted that adenomyosis 1, 2 degrees has a good prognosis with timely treatment with modern means.

    Features 3 and 4 stages

    The following stages of the pathology (3rd and 4th) are characterized by excruciating, intolerable pains in the lower abdomen. More often - before menstruation. In addition to them: hormonal disorders, severe menstrual bleeding, which causes anemia. There is also a decrease in immunity, especially if the pathology is hereditary. To restore it, a woman should take immunostimulants.

    Treatment 3 and 4 stages

    For the treatment of complex forms of the disease (grade 3, 4), gonadotropin is prescribed - releasing hormones or their analogues. The latter include:

    These drugs affect the ovaries, as a result, the appendages stop their secretory function. The patient ceases to go monthly, the level of sex hormones in the blood decreases. After treatment, the functional abilities of the appendages are returned, therefore, in addition to painkillers, hemostatic hormones, drugs that suppress the growth of the endometrium are prescribed. For example: Byzanna (active ingredient Dienogest).

    This medicine (Vizanna) causes heavy uterine bleeding, so its independent use is prohibited. Treatment of Visanna is carried out only under the supervision of a gynecologist.

    Valuable Byzanna

    The drug is sold in the form of 2 mg tablets. In one pack 2 blisters of 14 tablets. Each blister has markings for the days of the week, which allows you to follow the medication and prevent gaps. The average cost of Byzanna is approximately 2500 rubles. In order to avoid fakes, it is recommended to acquire it only in the checked drugstores or medical institutions. Do not forget to check the expiration date, the presence of blisters and the external state of the package, without departing from the cash register.

    vizanna analogs of the drug

    Analogues byzanzan with adenomyosis

    - FEMIKAPS ISI LIFE. Recommended for the treatment of diseases associated with the destabilization of the hormonal state of the patient. In addition, gynecologists prescribe it for general strengthening of the body, as well as to eliminate such afflictions as pain during menstruation, menopausal disorders and endometriosis.

    - LUTEIN. The drug is intended for patients with unstable menstrual cycle. Also, the drug may be prescribed to women who are preparing for artificial insemination or to prevent the threat of miscarriage, as well as infertility.

    - INDOL-3. It can be assigned to women as a means to strengthen the body, improve hormonal and emotional background, eliminate interruptions in the menstrual cycle and relieve pain, as well as reduce the risk of breast cancer.

    - STELLA. This drug can be prescribed as a prophylactic agent after the treatment of uterine fibroids, endometriosis, or after surgery on the reproductive female organs. It can also be used to prevent the recurrence of a cured disease.

    Features of the drug

    Take the drug should be strictly on the instructions of the gynecologist, who, after carefully examining the history of your illness, write out a prescription and give the necessary recommendations for the use of this medicine. While undergoing treatment with the help of Vizann, you will be able to notice how it will effectively ease lower abdominal pain during the menstrual cycle, the pain during intimacy will disappear, and also improve the patient's hormonal and emotional background. In addition, individual intolerance to the drug may occur, such as nausea, drowsiness, headache, and an increase in body weight.

    feedback when taking visanna

    The drug is not the cheapest, but very effective. Приобретала «Визанну» для моей сестры, которая на протяжении долгого времени пыталась забеременеть, но все попытки оказывались безрезультатными.Then she turned for help to specialists, passed the necessary tests, diagnosed endometriosis, made laparoscopy and was appointed to take "Vizanna". After 5 months, she became pregnant.

    Glafira Yuryevna, 32 years

    Good time of day! I want to share with you my impressions of the drug "Vizanna." She was treated for half a year. Before that, I was diagnosed with endometriosis, which was accompanied by terrible lower abdominal pains and attempts to become pregnant, but there was no positive result. After the treatment of Visanna, everything went away, and literally after a month I was able to get pregnant. Now my child is 5 months old.

    After the doctors diagnosed endometriosis, Vizanna was treated for a year, after which all pains and afflictions passed. She was pleased with the medicine, with the exception of weight gain.

    Good day. I accept the Vizanna 4th month, the pain has passed, the ultrasound showed positive results and that I am recovering. The drug helped a lot, except for constant nausea during the first time of treatment.

    The doctor appointed me "Vizanna" after laporaskopii. Start taking on the first day of your period. Monthly after reception of a vizanna were usual. For the first time no side effects did not disturb, treatment took place without problems. For myself, I decided to take a pill for the night to avoid appetite. Consequently, after the first 30 days of use of the drug, the weight gain did not happen, the mood is good and the pain has decreased significantly.

    Before you start taking the drug, it is strongly recommended to consult with your gynecologist, pass the necessary tests to identify the disease and only then begin treatment, following the prescribed recommendations of a specialist.

    Use of the drug Byzanne for the treatment of endometriosis

    An extremely unpleasant situation for a woman with any type of endometriotic disease is the inability to bear children. Vizanna with endometriosis helps reduce the severity of symptoms and create conditions for the successful conception of a baby. The drug has many advantages that are used to treat pathology, but there are drawbacks and side effects associated with long-term medication. Therefore, a hormonal agent is used as prescribed by the doctor and under mandatory medical supervision. Instructions for use indicate the main indication for therapy - endometriosis, and the reviews of doctors convincingly show that with the help of the drug you can remove pain and gain the happiness of motherhood.

    The composition and properties of the drug

    The basis of the drug is Dienogest at a dose of 2 mg. This biologically active substance with progesterone action has the following positive effects:

  • restoration of hormonal balance with a decrease in estrogenic effects on the reproductive organs,
  • inhibition of excessive thickening of the endometrium,
  • reducing the number of nerve endings in endometriotic foci, which provides pain relief,
  • inhibiting the growth and spread of new arterial vessels feeding the foci of endometriosis,
  • the death of endometrial cell structures in an atypical location
  • impact on the inflammatory process, present in the background of the disease,
  • suppression of the production of prostaglandins (substances that create the conditions for pain).

    The drug has a minimal effect on ovulation, which creates conditions for the possibility of pregnancy. Reviews of doctors show that the probability of the desired conception in women with endometriosis after the end of the reception of Vizanna is significantly higher.

    Instructions for use indicates the main indication for the use of Vizanna - endometrial disease. The main goals for therapy are:

  • reduction of pain associated with menstruation,
  • removal of pain in the intermenstrual period,
  • impact on the severity of uterine bleeding during menstruation,
  • creating the conditions for the desired conception.

    Dienogest works great as part of complex therapy, but you can use the drug Vizanna for the treatment of endometriosis without the use of other drugs. It is important to follow accurate recommendations using the prescribed treatment regimen.

    Treatment involves the continuous intake of the drug, 1 tablet per day for at least 6 months. It is very important to get a semi-annual treatment regimen to obtain a positive effect.

    Instructions for use allow the beginning of the medication from any day of the cycle, but it is desirable to start treatment with 1 day of menstruation, and in the future you can drink pills in a continuous mode, and do not pay attention to bleeding on the days of expected menstruation.

    The doctor may recommend the drug immediately after the detection of endometriosis with 1 or 2 degrees of the spread of the disease. A good option is a course of therapy after surgery to remove an endometrioid tumor of the ovary or uterus. In each case, the choice is individual: a variety of types of endometriosis makes the doctor creatively approach the treatment of the disease.

    The positive effects of the drug

    Visanna, in compliance with the recommendations of the doctor provides:

  • reduction of pain or the complete disappearance of pain,
  • correction of the menstrual cycle with a decrease in the amount of blood lost in menstruation,
  • qualitative changes of the endometrium, which in the future may become the basis for successful conception and gestation,
  • normalization of hormonal balance in the female body.

    Visanna is not a means to prevent pregnancy, but during the course of therapy, the possibility of conception is minimal.

    The reason for this is that the endometrium erupts in the uterus and the fertilized egg cannot attach to the wall. However, immediately after the end of taking the pills in the first months, the chances of the desired approach of pregnancy are very high. Conception and gestation can be one of the effective methods of treating endometriotic disease, therefore, after the course of therapy, it is advisable to become pregnant, bear, give birth and feed the baby.

    The drug belongs to the drugs for the production of which are used high-tech methods of pharmacology, so the price of the drug is quite high. This must be taken into account, especially against the background of a six-month course of treatment with daily pills. However, the advantages of Vizanna and guaranteed efficacy of therapy are becoming the main factor for choosing this treatment option for endometriotic disease.

    Adenomyosis is one of the most common ailments in women. This disease is characterized by pathological proliferation of endometrial cells, which adversely affects the reproductive system and overall women's health.

    Adenomyosis has four stages of development. each of which is distinguished by the extensive damage of the genital organs and the depth of penetration of the expanding cells into the tissue. However, the diagnosis of adenomyosis is not a sentence, since this ailment is benign and very rarely turns into oncology.

    Treatment of adenomyosis is prescribed for each patient individually. After the diagnosis is made by the doctor, the most appropriate drug is selected, which in the course of therapy stops the uncontrolled growth of cells.

    So, drug therapy is necessary only if the woman has the following complaints:

  • disruptions in the cycle, characterized by delayed menstruation,
  • painful and too heavy periods,
  • pain in the lower abdomen in the middle of the cycle and before the onset of menstruation,

    pronounced symptoms of adenomyosis. especially for women of childbearing age

    Preparations for the treatment are selected in accordance with some factors that must always be considered for successful treatment, namely:

  • the presence of contraindications to the existing components of the drug,
  • age of the patient

    In addition, prescribing medications, should consider whether or not the patient plans to become a mother at the time of going to the doctor.

  • drugs that contain synthetically reduced estrogen,
  • hormonal based on progesterone,
  • medications with hormone gonadotropin or similar substances.

    A popular and fairly effective drug for adenomyosis is Janine. He is known by many women, as these pills are often used as contraception.

    Main Janine is:

    The first hormone inhibits the pathological proliferation of endometrial cells, which suppresses the development of adenomyosis until it disappears completely. Estrogen, in turn, activates the growth of the ovarian follicle, which contributes to ovulation.

    The hormonal drug Duphaston contains an artificial analogue of natural progesterone, which is secreted in a woman's body during ovulation by the yellow body of the ovary.

    It is because of insufficient release of progesterone that such a disease as adenomyosis often develops. Therefore, Duphaston therapy is prescribed in most cases of the disease and is quite effective.

    Means Byzanna with adenomyosis is assigned quite often. The drug has a firming effect on the uterine mucosa and has a gestagenic effect.

    The hormone dienogest, which is part of Vizann, reduces the intensity of reproduction of endometrial cells of the uterus by inhibiting the production of estrogen.

    If during treatment with this drug to adhere to all the recommendations of the attending physician, then you can quickly stop the further development of the disease and prevent the emergence of new foci of pathological proliferation of endometrial cells.

    To consolidate a positive result and prevent recurrence of Bezanne adenomyosis, it is necessary to take at least six months, but always under the supervision of a specialist.

    The basis of Orgametril is the hormone linestrenol. It tends to suppress ovulation and delay menstruation. With adenomyosis, this drug is prescribed to normalize the production of progesterone, the lack of which leads to impaired cellular growth in the uterine cavity.

    Orgametril should be taken at least 6 months. It is with long-term treatment with linestrenol that the complete disappearance of the pathological foci of endometriotic cells can be achieved and the reproductive function can be improved.

    Clayra's hormonal agent is often used in gynecology for the treatment of adenomyosis. It effectively eliminates further uncontrolled reproduction of endometrial cells and inhibits activity in the existing foci.

    Clayra contains two hormones: dienogest, which is an analogue of organic progesterone, and a large amount of estrogen.

    The indications for the installation of the Mirena helix are:

    • painful menstruation,
    • intermenstrual smearing periodic discharge.

    Mirena is appointed exclusively by the gynecologist, the same applies to her installation. In no case should you try to put the helix into the uterus.

    The drug Silhouette is an analogue of such a hormonal agent, as Jeanine. It contains two hormones, one of which suppresses the development of pathological foci, and the second promotes the maturation of the follicle, which ensures timely ovulation.

    Silhouette in adenomyosis is often used as an analogue of more expensive drugs. But, despite its lower cost, it is quite effective and has a minimum of side effects, as it belongs to the medicines of the new generation.

    Regulon is better known among women as a means of contraception.

    It contains:

    30 mcg ethinyl estradiol,

    Zoladex suppresses the production of natural estrogen, which stops the further growth of endometrial cells and prevents the further development of foci.

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